AI Article Synopsis
- Iron oxide impregnated casein nanoparticles (IOICNPs) were created using a method that combines iron oxide with a casein protein matrix.
- Various characterization techniques, including SEM and XPS, confirmed the successful incorporation of iron oxide and its oxidation state.
- The swelling behavior in a phosphate buffer revealed that factors like chemical composition, pH, temperature, and magnetic fields affect their water absorption, suggesting their potential use in targeted cancer drug delivery.
Article Abstract
Iron oxide impregnated casein nanoparticles (IOICNPs) were prepared by in-situ precipitation of iron oxide within the casein matrix. The resulting iron oxide impregnated casein nanoparticles (IOICNPs) were characterized by Scanning electron microscopy (SEM), Transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared (FTIR), Vibrating sample magnetometer (VSM) and Raman spectroscopy. The FTIR analysis confirmed the impregnation of iron oxide into the casein matrix whereas XPS analysis indicated for complete oxidation of iron (II) to iron(III) as evident from the presence of the observed representative peaks of iron oxide. The nanoparticles were allowed to swell in phosphate buffer saline (PBS) and the influence of factors such as chemical composition of nanoparticles, pH and temperature of the swelling bath, and applied magnetic field was investigated on the water intake capacity of the nanoparticles. The prepared nanoparticles showed potential to function as a nanocarrier for possible applications in magnetically targeted delivery of anticancer drugs.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189755 | PMC |
| http://dx.doi.org/10.1186/s12951-014-0038-4 | DOI Listing |
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