Syringoid eccrine carcinoma is a very rare skin cancer. We present a case of a 22-year-old woman with a presentation of syringoid eccrine carcinoma in the subungual region of the hallux. This clinical case demonstrates our work-up that led to a proper diagnosis and management of this pathology. We discuss our surgical procedure of choice and the outcome. This report adds valuable information to a limited database of knowledge available on the diagnosis and management of syringoid eccrine carcinomas.

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http://dx.doi.org/10.7547/0003-0538-104.5.504DOI Listing

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Article Synopsis
  • - Syringoid eccrine carcinoma (SEC) is a rare and aggressive skin cancer that typically appears as nodules or plaques, often in the head, neck, or trunk, making it challenging to diagnose due to its varied appearance.
  • - The cancer exhibits unique growth patterns characterized by infiltrative behavior and potential to spread, with histological features resembling syringomas and showing ductular differentiation.
  • - This text discusses a rare case of SEC found in the nipple of a 51-year-old male, marking only the second documented instance of this condition in a male patient, and it was complicated by metastasis to the axillary lymph nodes.
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ROS1 Fusion Angiomatoid Spitz Nevus With Eccrine Duct Fibroadenomatosis and Syringoid Features.

Am J Dermatopathol

November 2023

Department of Dermatopathology, St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.

Eccrine duct fibroadenomatosis is a reactive histological phenomenon observed in a variety of inflammatory and neoplastic pathologies. We report a case of a ROS1 fusion angiomatoid Spitz nevus with associated acrosyringeal hyperplasia and a syringoma-like ductal proliferation in a young female patient.

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Neoplasms of sweat glands and the breast may be morphologically and immunophenotypically similar. A recent study showed that TRPS1 staining is a highly sensitive and specific marker for breast carcinoma. In this study, we analyzed TRPS1 expression in a spectrum of cutaneous sweat gland tumors.

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