Synovial sarcoma of the ethmoidal sinus.

J Laryngol Otol

Department of Otorhinolaryngology, University of Malaya,Kuala Lumpur,Malaysia.

Published: November 2014

AI Article Synopsis

  • Synovial sarcoma is a rare and aggressive cancer, mostly found in extremities, with only a small percentage occurring in the head and neck, such as the ethmoidal sinus.
  • An 80-year-old woman diagnosed with synovial sarcoma after experiencing nasal bleeding underwent surgery to remove the tumor.
  • The prognosis for patients with this type of cancer is typically poor, often leading to death within a year despite surgery and post-operative radiotherapy.

Article Abstract

Background: Synovial sarcoma is a high-grade, soft tissue, malignant disease associated with poor outcome. Typically, synovial sarcoma involves the extremities, with less than 10 per cent of cases occurring in the head and neck region. Synovial sarcoma of the paranasal sinuses is a rare entity. This paper presents a case of an elderly patient with synovial sarcoma of the ethmoidal sinus.

Case Report: An 80-year-old woman who had right epistaxis underwent nasal endoscopy and biopsy. The pathology indicated synovial sarcoma and the patient underwent endoscopic excision of the tumour.

Conclusion: Synovial sarcoma of the ethmoidal sinus is very rare. Patients should undergo excision of the tumour with post-operative radiotherapy. However, the prognosis remains poor and usually the patient succumbs to death within a year.

Download full-text PDF

Source
http://dx.doi.org/10.1017/S0022215114002151DOI Listing

Publication Analysis

Top Keywords

synovial sarcoma
28
sarcoma ethmoidal
12
ethmoidal sinus
8
synovial
7
sarcoma
6
sinus background
4
background synovial
4
sarcoma high-grade
4
high-grade soft
4
soft tissue
4

Similar Publications

Synovial Chondromatosis of the Hand and Wrist: A 35-Year Retrospective Case Review.

J Hand Surg Asian Pac Vol

January 2025

Auckland Regional Centre for Plastic, Reconstructive and Hand Surgery, Middlemore Hospital, Auckland, New Zealand.

Synovial chondromatosis is a condition that rarely occurs in the hand and wrist. Recurrence and malignant transformation are two potential complications of the disease. We set out to retrospectively review 35 years of practice within our sarcoma and tertiary hand unit and identify recurrence or malignant transformation.

View Article and Find Full Text PDF

A case of synovial sarcoma of the right mid-thigh and literature review.

Oncol Rev

December 2024

Department of Ultrasound, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.

Synovial sarcoma (SS) is a rare and malignant mesenchymal neoplasm. We report a case of a 16-year-old Chinese female diagnosed with biphasic synovial sarcoma. The imaging features, surgical procedures and pathological results of the lesion were described in detail.

View Article and Find Full Text PDF

The adoptive transfer of TCR-T cells specific to neoantigens preferentially exhibits potent cytotoxicity to tumor cells and has shown promising efficacy in various preclinical human cancers. In this study, we first identified a functional TCR, Tcr-1, which selectively recognized the SYT-SSX fusion neoantigen shared by most synovial sarcomas. Engineered T-cell expressing Tcr-1 (Tcr-T1) demonstrated HLA-A*2402-restricted, antigen-specific anti-tumoral efficacy against synovial sarcoma cells, both in vitro and in vivo.

View Article and Find Full Text PDF

Sarcomas are a rare type of malignancy with limited treatment options so far. This analysis aimed to describe the impact of lymphadenectomy on treating sarcoma patients. Sarcomas characterized by lymphatic spread are rare.

View Article and Find Full Text PDF

The present study was a retrospective single-center study. A total of 81 patients diagnosed with metastatic soft tissue sarcoma were included who received pazopanib therapy. Clinical data, including age at diagnosis, histological subtype, treatments received before pazopanib, number of metastatic sites at the time of initiation of treatment, progression-free survival and overall survival time under pazopanib treatment, side effects and response evaluation in follow-up imaging after initiation of pazopanib therapy, were recorded.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!