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Fixation Stability Deficits in Anisometropic Amblyopia.

Invest Ophthalmol Vis Sci

January 2025

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Sun Yat-Sen University, Guangzhou, China.

Purpose: The purpose of this study was to investigate the relationship between fixation stability deficits in anisometropic amblyopia and various visual functions, as well as the underlying retinal structure.

Methods: All 164 patients with anisometropic amblyopia were recruited in this cross-sectional study. The contrast sensitivity function (CSF) was measured using the qCSF method, whereas the MP-3 microperimeter was used to assess fixation stability and locate the preferred retinal locus.

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In amblyopia, abnormal binocular interactions lead to an overwhelming dominance of one eye. One mechanism implied in this imbalance is the suppression between the inputs from the two eyes. This interocular suppression involves two components: an overlay suppression and a surround suppression.

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Purpose: This study uses eye tracking to investigate how varying fellow eye (FE) contrast during dichoptic video viewing influences eye movement patterns, and their associations with interocular suppression, visual acuity, and stereoacuity deficit in amblyopia.

Methods: Eye movements of 27 amblyopic and 8 healthy control participants were recorded during dichoptic viewing of stationary dots and videos with FE contrasts (100%, 50%, 25%, and 10%). Analysis included durations the amblyopic and FE spent in different stimulus regions, fixation switches, and eye deviation, and correlating these with suppression, visual acuity, and stereoacuity.

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Article Synopsis
  • A study evaluated three treatments for amblyopia in children, comparing two methods that included patching with active vision therapy and one method that used patching alone.
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  • The findings suggest that effective amblyopia treatment should involve active vision exercises alongside patching to enhance visual performance, particularly for children with poorer initial vision.
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Article Synopsis
  • Visual evoked potential (VEP) is a non-invasive method used to identify visual system abnormalities, particularly useful for young children who can't communicate visual issues.
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