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Detection and characterization of new mangromicin analogs by tandem mass spectrometry.
Biosci Biotechnol Biochem
November 2022
Division of Disease Proteomics, Institute for Enzyme Research, University of Tokushima, 3-18-15 Kuramoto-cyo, Tokushima, Japan.
Many useful natural products are usually screened based on their biological activities. On the other hand, various natural products can be detected based on their physicochemical properties. We have already reported the isolation and characterization of mangromicins from a cultural broth of Lechevalieria aerocolonigenes K10-0216 using physicochemical screening.
View Article and Find Full Text PDFMangromicin C, a new analog of mangromicin.
J Antibiot (Tokyo)
March 2015
Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan.
Mangromicins, six new anti-oxidative agents isolated from a culture broth of the actinomycete, Lechevalieria aerocolonigenes K10-0216.
J Antibiot (Tokyo)
July 2014
Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan.
We have been continually searching for novel chemical compounds from culture broths of various actinomycetes using a physicochemical screening system. During the course of this program, we have previously reported the discovery of two new natural products, designated mangromicins A and B, discovered in a broth of a rare actinomycete strain, Lechevalieria aerocolonigenes K10-0216. Mangromicins have a unique and rare structure, a cyclopentadecane skeleton with a tetrahydrofuran unit and a 5,6-dihydro-4-hydroxy-2-pyrone moiety.
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