Aim: This work aims to summarize the experience in emergency microsurgery for patients with aneurysmal subarachnoid hemorrhage (SAH) that coexisted with brain hernia.
Material And Methods: A total of 26 patients with aneurysmal SAH complicated by brain hernia were subjected to emergency aneurysm clamping + decompressive craniectomy. 10 patients were diagnosed with aneurysmal SAH coexisted with brain hernia before operation.
Results: Four patients had a carotid aneurysm, 15 had a middle artery aneurysm, and 7 had an anterior communicating aneurysm. The surgical procedure was performed smoothly for all patients. The patients were followed up for 3 months to 6 months. According to Glasgow outcome scaling, five patients recovered well, six suffered from moderate disability, five were subjected to severe disability, five were in plant survival, and 5 died.
Conclusion: Emergency surgical exploration is an effective treatment method for patients.
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http://dx.doi.org/10.5137/1019-5149.JTN.9283-13.2 | DOI Listing |
Int J Mol Sci
January 2025
Department of Molecular Biology and Genetics, Çanakkale Onsekiz Mart University, Çanakkale 17100, Turkey.
Fucosidosis is a rare lysosomal storage disease caused by α-L-fucosidase deficiency following a mutation in the gene. This enzyme is responsible for breaking down fucose-containing glycoproteins, glycolipids, and oligosaccharides within the lysosome. Mutations in result in either reduced enzyme activity or complete loss of function, leading to the accumulation of fucose-rich substrates in lysosomes.
View Article and Find Full Text PDFTaiwan J Obstet Gynecol
January 2025
Department of Obstetrics & Gynecology, Iizuka Hospital, Fukuoka, Japan.
Objectives: The main objective of this case report is to discuss the differentiation between hyperemesis gravidarum and a brain tumor in the presence of hyperemesis symptoms in the first trimester of pregnancy.
Case Report: A patient was initially diagnosed with hyperemesis gravidarum in early pregnancy and was hospitalized. After hospitalization, cerebral hemorrhage and cerebral hernia due to convulsions occurred.
PLoS One
January 2025
Department of Convergence of Healthcare and Medicine, Ajou University Graduate School of Medicine, Suwon, South Korea.
Brain herniation can be a life-threatening condition, resulting in poor prognosis and higher fatality rates. We examined whether quantitative characteristics of sequential pupillary light reflex (PLR) could serve as biomarkers for identifying brain herniation in fatal acute stroke cases with anterior circulation involvement admitted to neurological intensive care unit (Neuro-ICU). Automatic pupillometer assessed PLR automatically every 4-6 hours, measuring eight specific features: NPi (Neurological pupil index) score, initial resting and constriction pupil size, constriction change, constriction velocity, constriction latency, and dilation velocity.
View Article and Find Full Text PDFInt J Biol Sci
January 2025
Department of Basic & Translational Sciences, School of Dental Medicine, University of Pennsylvania, USA.
Inositol polyphosphate-5-phosphatase E (INPP5E) is a 5-phosphatase critically involved in diverse physiological processes, including embryonic development, neurological function, immune regulation, hemopoietic cell dynamics, and macrophage proliferation, differentiation, and phagocytosis. Mutations in cause Joubert and Meckel-Gruber syndromes in humans; these are characterized by brain malformations, microphthalmia, situs inversus, skeletal abnormalities, and polydactyly. Recent studies have demonstrated the key role of INPP5E in governing intracellular processes like endocytosis, exocytosis, vesicular trafficking, and membrane dynamics.
View Article and Find Full Text PDFIn Vivo
December 2024
Department of Neuroradiology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Background/aim: Congenital diaphragmatic hernia (CDH) is a critical condition affecting newborns, which often results in long-term morbidities, including neurodevelopmental delays, which affect cognitive, motor, and behavioral functions. These delays are believed to stem from prenatal and postnatal factors, such as impaired lung development and chronic hypoxia, which disrupt normal brain growth. Understanding the underlying mechanisms of these neurodevelopmental impairments is crucial for improving prognosis and patient outcomes, particularly as advances in treatments like ECMO have increased survival rates but also pose additional risks for neurodevelopment.
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