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From bistate molecular switches to self-directed track-walking nanomotors. | LitMetric

From bistate molecular switches to self-directed track-walking nanomotors.

ACS Nano

Department of Physics, ‡NUS Graduate School for Integrative Sciences and Engineering, §Center for Computational Science and Engineering, National University of Singapore, Singapore 117542.

Published: October 2014

AI Article Synopsis

  • Track-walking nanomotors are crucial for practical uses of nanotechnology, but their development is challenging compared to simpler nanodevices like switches.
  • The main issue is the lack of modular design that separates engine and leg functions, which currently exist together in the same molecular structure.
  • This research introduces a new design principle for modular nanomotor construction, demonstrated by a bipedal DNA nanomotor that uses light to create coordinated, directional movement on a DNA track.

Article Abstract

Track-walking nanomotors and larger systems integrating these motors are important for wide real-world applications of nanotechnology. However, inventing these nanomotors remains difficult, a sharp contrast to the widespread success of simpler switch-like nanodevices, even though the latter already encompasses basic elements of the former such as engine-like bistate contraction/extension or leg-like controllable binding. This conspicuous gap reflects an impeding bottleneck for the nanomotor development, namely, lack of a modularized construction by which spatially and functionally separable "engines" and "legs" are flexibly assembled into a self-directed motor. Indeed, all track-walking nanomotors reported to date combine the engine and leg functions in the same molecular part, which largely underpins the device-motor gap. Here we propose a general design principle allowing the modularized nanomotor construction from disentangled engine-like and leg-like motifs, and provide an experimental proof of concept by implementing a bipedal DNA nanomotor up to a best working regime of this versatile design principle. The motor uses a light-powered contraction-extension switch to drive a coordinated hand-over-hand directional walking on a DNA track. Systematic fluorescence experiments confirm the motor's directional motion and suggest that the motor possesses two directional biases, one for rear leg dissociation and one for forward leg binding. This study opens a viable route to develop track-walking nanomotors from numerous molecular switches and binding motifs available from nanodevice research and biology.

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Source
http://dx.doi.org/10.1021/nn5034983DOI Listing

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