Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Peginterferon lambda for the treatment of HBeAg-positive chronic hepatitis B: A randomized phase 2b study (LIRA-B).
J Hepatol
May 2016
Bristol-Myers Squibb Research and Development, Wallingford, CT, USA. Electronic address:
Background & Aims: Peginterferon lambda-1a (lambda) is a Type-III interferon, which, like alfa interferons, has antiviral activity in vitro against hepatitis B virus (HBV) and hepatitis C virus (HCV); however, lambda has a more limited extra-hepatic receptor distribution. This phase 2b study (LIRA-B) evaluated lambda in patients with chronic HBV infection.
Methods: Adult HBeAg+ interferon-naive patients were randomized (1:1) to weekly lambda (180 μg) or peginterferon alfa-2a (alfa) for 48 weeks.
Interferon alfa-associated depression in patients with Behçet's syndrome: a prospective controlled study.
Clin Exp Rheumatol
December 2014
Division of Rheumatology, Department of Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Turkey.
Serotonin-norepinephrine reuptake inhibitor desvenlafaxine for the treatment of interferon alfa-associated depression in patients with hepatitis C.
Braz J Psychiatry
November 2014
Tropical Medicine Program, School of Medicine, UFMG, Belo Horizonte, MG, Brazil.
Antidepressant pretreatment for the prevention of interferon alfa-associated depression: a systematic review and meta-analysis.
Psychosomatics
June 2015
Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany; Department of Psychiatry, Psychotherapy and Addiction Medicine, Kliniken Essen-Mitte, Essen, Germany. Electronic address:
Background: Depression is a major complication during treatment with interferon alfa (IFN-α).
Aim: The aim of this study was to clarify whether preemptive antidepressant treatment can reduce the incidence and severity of IFN-associated depression.
Method: Based on a systematic review of the literature up to July 2012, a meta-analysis of the data from 8 trials investigating patients with malignant melanoma or hepatitis C was performed.
Low rate of sustained virological response in an outbreak of acute hepatitis C in HIV-infected patients.
AIDS Res Hum Retroviruses
October 2012
Infectious Diseases, University of Barcelona, Spain.
Recent reports have suggested an increased risk of acute hepatitis C (AHC) infection in homosexual HIV-infected men and that early treatment with interferon-alfa, alone or associated with ribavirin, significantly reduces the risk of chronic evolution. A retrospective analysis of 38 HIV-infected patients who were consecutively diagnosed as developing AHC, defined by both seroconversion of anti-hepatitis C virus (HCV) antibodies and detection of serum HCV-RNA in those with previous negative results. Thirty-six patients were men with history of unprotected sexual intercourse with men and two were women with sexual and nosocomial risk factors.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!