This is the protocol for a review and there is no abstract. The objectives are as follows: To determine the efficacy of venlafaxine in comparison with other anti-depressive agents in alleviating the acute symptoms of major depressive disorder.To review acceptability of treatment with venlafaxine in comparison with other anti-depressive agents.To investigate the adverse effects of venlafaxine in comparison with other anti-depressive agents.
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http://dx.doi.org/10.1002/14651858.CD006530 | DOI Listing |
Phytomedicine
January 2025
Heilongjiang University of Chinese Medicine, Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Traditional Chinese medicine (TCM) biological genetics (Heilongjiang province double first-class construction interdiscipline), Heilongjiang Touyan Innovation Team Program, 150040, China. Electronic address:
Background: The major depressive disorder (MDD) is a heterogeneous condition and characterized by a high recurrence rate, with neuroinflammation playing a significant role in its various potential pathologies. In recent years, neuronal pyroptosis induced by neuroinflammation has garnered increasing attention in depression research. Bupleurum scorzonerifolium Willd.
View Article and Find Full Text PDFFront Pharmacol
October 2024
The College of Pharmacy Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Background: In recent years, the incidence of depression, recognized as a serious psychological disorder, has escalated rapidly. (Scrophulariaceae; Rehmanniae Radix, Crude drug) and (Liliaceae; Lilii bulbus, Crude drug) constitute a classic anti-depressant combination, exhibiting pharmacological effects that include anti-depressive, anti-anxiety, and anti-inflammatory properties. Current clinical studies have demonstrated that Baihe Dihuang Decoction, a traditional Chinese herbal compound, is effective in treating depression.
View Article and Find Full Text PDFJ Ethnopharmacol
February 2025
Jilin Provincial Key Laboratory for Molecular and Chemical Genetics, The Second Hospital of Jilin University, Changchun, 130041, PR China; Engineering Laboratory for Screening of Antidepressant Drugs, Jilin Province Development and Reform Commission, Changchun, 130041, PR China; Jilin Provincial Key Laboratory on Target of Traditional Chinese Medicine with Anti-depressive Effect, Changchun, 130041, PR China. Electronic address:
Ethnopharmacological Relevance: Fuzi-Lizhong pill (FLP) is a well-validated traditional Chinese medicine (TCM) formula that has long been used in China for gastrointestinal disease and adjunctive therapy for depression. In our previous study, we reported that the principal herb of FLP, Aconitum carmichaelii Debx. (Fuzi), exhibits antidepressant-like effects.
View Article and Find Full Text PDFClin Pharmacol Ther
January 2025
Clinical Pharmacology and Pharmacometrics, Janssen Research & Development LLC, La Jolla, California, USA.
The use of partial residual plots (PRPs) was explored as a model diagnostic tool in Model-based Meta-Analysis (MBMA). Mathematical derivations illustrating the concepts were followed by an MBMA example using publicly available literature data of anti-depressive treatments with fluoxetine and venlafaxine. An E dose-response model was identified for venlafaxine while a constant drug effect combining all dose levels vs.
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