Gordon L. Paul was a foundational scholar in the transformation of clinical psychology from its beginnings in anecdotal, largely untestable explanation and practice to the evidence-based assessment and intervention that currently characterize the field. Gordon was one of the most highly cited researchers of his time and had a profound influence on the development of modern-day clinical research. (PsycINFO Database Record (c) 2014 APA, all rights reserved).
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Relationship Between Severity of Ischemia and Coronary Artery Disease for Different Stress Test Modalities in the ISCHEMIA Trial.
Circ Cardiovasc Interv
December 2024
Cardiovascular Clinical Research Center, Department of Medicine, NYU Grossman School of Medicine, New York, NY (H.R.R., L.P., S.B., J.S.H.).
Background: The relationship between the extent and severity of stress-induced ischemia and the extent and severity of anatomic coronary artery disease (CAD) in patients with obstructive CAD is multifactorial and includes the intensity of stress achieved, type of testing used, presence and extent of prior infarction, collateral blood flow, plaque characteristics, microvascular disease, coronary vasomotor tone, and genetic factors. Among chronic coronary disease participants with site-determined moderate or severe ischemia, we investigated associations between ischemia severity on stress testing and the extent of CAD on coronary computed tomography angiography.
Methods: Clinically indicated stress testing included nuclear imaging, echocardiography, cardiac magnetic resonance imaging, or nonimaging exercise tolerance test.
Pericardial Fluid of Patients With Coronary Artery Disease Can Drive Fibrosis Via TGF-Beta Pathway.
JACC Basic Transl Sci
November 2024
Section of Cardiac Surgery, Department of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Article Synopsis
- Human pericardial fluid (PF) contains biologically active markers that have significant effects on heart-related cellular activities.
- PF can enhance the activity of cardiac fibroblasts, which are important for heart tissue repair, through a specific biological pathway known as the transforming growth factor-β pathway.
- In patients with coronary artery disease, the PF possesses a higher capacity to promote fibrosis compared to those without the disease, indicating a potential area for clinical attention.
Characteristics, Trends, and Outcomes of Intravascular Lithotripsy-Assisted Transfemoral Transcatheter Aortic Valve Replacement in United States.
JACC Cardiovasc Interv
October 2024
Lifespan Cardiovascular Institute, Providence, Rhode Island, USA; Department of Medicine, Division of Cardiology, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA. Electronic address:
Background: Transfemoral (TF) access is the preferred approach for transcatheter aortic valve replacement (TAVR). Limited data exist regarding the outcomes of intravascular lithotripsy (IVL)-assisted TF TAVR in patients with peripheral artery disease.
Objectives: This study sought to examine contemporary characteristics, trends, and outcomes of IVL TAVR in the United States.
The Canadian VirusSeq Data Portal and Duotang: open resources for SARS-CoV-2 viral sequences and genomic epidemiology.
Microb Genom
October 2024
Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada.
Article Synopsis
- The COVID-19 pandemic spurred global efforts to sequence SARS-CoV-2 genomes to monitor its evolution and guide public health decisions, resulting in millions of genome sequences being shared worldwide.
- The Canadian COVID-19 Genomics Network (CanCOGeN - VirusSeq) launched the Canadian VirusSeq Data Portal to provide open access to genomic sequences and standardized contextual data while adhering to FAIR standards.
- The portal emphasizes data quality, privacy compliance, and security, and is used alongside tools like Viral AI and the CoVaRR-Net to facilitate ongoing research and analysis of SARS-CoV-2 variants in Canada.
Two-year follow-up of transcatheter aortic valve replacement in low-risk patients with symptomatic severe bicuspid aortic valve stenosis.
Catheter Cardiovasc Interv
September 2024
Section of Interventional Cardiology, MedStar Washington Hospital Center, Washington, USA.
Background: In 2019, the US Food and Drug Administration (FDA) approved transcatheter aortic valve replacement (TAVR) for low-risk patients with symptomatic severe tricuspid aortic stenosis. However, bicuspid aortic valve (BAV) patients were included only in single-arm registries of pivotal low-risk TAVR trials, resulting in limited data for this subgroup.
Methods: The LRT (Low Risk TAVR) trial was an investigator-initiated, prospective, multicenter study and the first FDA-approved investigational device exemption trial to evaluate the feasibility of TAVR with balloon-expandable or self-expanding valves in low-risk patients with symptomatic severe BAV stenosis.
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