Synthesis and evaluation of 9-deoxy analogues of (-)-thysanone, an inhibitor of HRV 3C protease.

Eur J Med Chem

School of Chemical Sciences, The University of Auckland, 23 Symonds St., Auckland 1142, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Private Bag 92019, Auckland Mail Centre, Auckland 1142, New Zealand. Electronic address:

Published: November 2014

9-Deoxy analogues of the HRV 3C protease inhibitor (-)-thysanone display better inhibitory properties than the natural product, inferring the C9-OH hinders binding to the enzyme.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejmech.2014.09.063DOI Listing

Publication Analysis

Top Keywords

9-deoxy analogues
8
hrv protease
8
synthesis evaluation
4
evaluation 9-deoxy
4
analogues --thysanone
4
--thysanone inhibitor
4
inhibitor hrv
4
protease 9-deoxy
4
analogues hrv
4
protease inhibitor
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!