The effect of the carbimazole on expression of tumor necrosis factor (TNF-α) in liver, was investigated in an experimental model of high fat diet (HFD) induced obesity. The HFD (orally given for 4 months) induced TNF-α in liver tissue along with raised serum triglyceride (TG), cholesterol and high TSH (62%). In carbimazole (1 mg/100 gbw) treatment, the induction of TNF-α was significantly inhibited, without affecting other parameters. It also improved the liver function, which was raised due to HFD in experimental control rats.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174658 | PMC |
| http://dx.doi.org/10.1186/s40200-014-0083-4 | DOI Listing |
Publication Analysis
Top Keywords
tnf-α liver
8
carbimazole inhibits
4
tnf-α
4
inhibits tnf-α
4
tnf-α expression
4
expression fat-induced
4
fat-induced hypothyroidism
4
hypothyroidism carbimazole
4
carbimazole expression
4
expression tumor
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!