Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4181365 | PMC |
| http://dx.doi.org/10.1161/CIRCRESAHA.114.304974 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Retinoic acid delays murine palatal shelf elevation by inhibiting Wnt5a-mediated noncanonical Wnt signaling and downstream Cdc-42/F-actin remodeling in mesenchymal cells.
Birth Defects Res
October 2023
Department of Stomatology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu Province, People's Republic of China.
Background: Mammalian palatal shelves erupted from maxillary prominences undergo vertical extention, transient elevation, and horizontal growth to fuse. Previous studies in mice reported that the retinoic acid (RA) contributed to cleft palate in high incidence by delaying the elevating procedure, but little was known about the underlying biological mechanisms.
Methods: In this study, hematoxylin-eosin and immunofluorescence staining were employed to evaluate the phenotypes and the expression of related markers in the RA-treated mice model.
Dickkopf-1 Can Lead to Immune Evasion in Metastatic Castration-Resistant Prostate Cancer.
JCO Precis Oncol
September 2020
Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY.
Purpose: Metastatic castration-resistant prostate cancer (mCRPC) with low androgen receptor (AR) and without neuroendocrine signaling, termed double-negative prostate cancer (DNPC), is increasingly prevalent in patients treated with AR signaling inhibitors and is in need of new biomarkers and therapeutic targets.
Methods: Candidate genes enriched in DNPC were determined using differential gene expression analysis of discovery and validation cohorts of mCRPC biopsies. Laboratory studies were carried out in human mCRPC organoid cultures, prostate cancer (PCa) cell lines, and mouse xenograft models.
A key 'foxy' aroma gene is regulated by homology-induced promoter indels in the iconic juice grape 'Concord'.
Hortic Res
April 2020
1US Department of Agriculture-Agricultural Research Service, Grape Genetics Research Unit, Geneva, NY USA.
Article Synopsis
- "Concord" grapes are known for their unique 'foxy' aroma, primarily caused by the chemical compound methyl anthranilate (MA), which some wine consumers find undesirable.
- Researchers discovered that specific genetic changes in the promoters of a key gene related to MA production play a significant role in how this aroma manifests in Concord grapes compared to other grape species.
- The study found that variations in promoter sequences are linked to higher expression and MA levels in Concord grapes, and these findings enhance understanding of the 'foxy' aroma trait, potentially aiding grapevine breeding efforts.
Identification and expression profiles of Fox transcription factors in the Yesso scallop (Patinopecten yessoensis).
Gene
April 2020
MOE Key Laboratory of Marine Genetics and Breeding, Ocean University of China, 5 Yushan Road, Qingdao 266003, China; Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, Shandong, China.
The forkhead box (Fox) gene family is a family of transcription factors that play important roles in a variety of biological processes in vertebrates, including early development and cell proliferation and differentiation. However, at present, studies on the mollusk Fox family are relatively lacking. In the present study, the Fox gene family of the Yesso scallop (Patinopecten yessoensis) was systematically identified.
View Article and Find Full Text PDFSynthetic presentation of noncanonical Wnt5a motif promotes mechanosensing-dependent differentiation of stem cells and regeneration.
Sci Adv
October 2019
Department of Biomedical Engineering, The Chinese University of Hong Kong, Sha Tin, New Territories 999077, Hong Kong, P. R. China.
Noncanonical Wnt signaling in stem cells is essential to numerous developmental events. However, no prior studies have capitalized on the osteoinductive potential of noncanonical Wnt ligands to functionalize biomaterials in enhancing the osteogenesis and associated skeleton formation. Here, we investigated the efficacy of the functionalization of biomaterials with a synthetic Wnt5a mimetic ligand (Foxy5 peptide) to promote the mechanosensing and osteogenesis of human mesenchymal stem cells by activating noncanonical Wnt signaling.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!