AI Article Synopsis
- AT1 receptor blockers (ARBs), like telmisartan, may help treat metabolic syndrome by lowering body weight and potentially improving leptin sensitivity, although the exact mechanism is unknown.
- In studies with diet-induced obese rats, telmisartan was shown to reduce weight gain and food intake without affecting blood pressure, while also normalizing leptin transport in the brain.
- The findings suggest that telmisartan preserves leptin sensitivity in rats on a high-fat diet, indicating its effects go beyond just lowering blood pressure.
Article Abstract
Background And Purpose: AT1 receptor blockers (ARBs) represent an approach for treating metabolic syndrome due to their potency in reducing hypertension, body weight and onset of type 2 diabetes. The mechanism underlying ARB-induced weight loss is still unclear.
Experimental Approach: Leptin resistance tests (LRTs) in diet-induced obese or lean rats were conducted to determine whether telmisartan (8 mg·kg(-1) ·day(-1) , 14 days) enhances leptin sensitivity. Phosphorylation of signal transducer and activator of transcription 3 (pSTAT3) staining was performed in hypothalami to determine leptin transport across the blood-brain barrier.
Key Results: Telmisartin reduced weight gain, food intake and plasma leptin but blood pressure remained unchanged. The 24 h profiles of plasma leptin after saline injections were similar in controls and telmisartan-treated rats, but after leptin injections were higher in controls and slightly lower in telmisartan-treated animals. After telmisartan, energy intake during LRT was lower in leptin- than in saline-pretreated rats, but remained unchanged in controls, irrespectively of whether rats received saline or leptin. Leptin minimized the gain in body weight during LRT in telmisartan-treated rats as compared with saline-treated animals. pSTAT3 staining was reduced in cafeteria diet-fed rats as compared with chow-fed rats but this was normalized by telmisartan. Telmisartin reduced hypothalamic mRNA levels of the orexigenic peptides melanin-concentrating hormone and prepro-orexin.
Conclusions And Implications: Rats fed a cafeteria diet develop leptin resistance after 2 weeks. Leptin sensitivity was preserved by telmisartan treatment even in rats fed a cafeteria diet. This pleiotropic effect is not related to the hypotensive action of telmisartan.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301694 | PMC |
| http://dx.doi.org/10.1111/bph.12949 | DOI Listing |
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