AI Article Synopsis
- TKA (total knee arthroplasty) and THA (total hip arthroplasty) carry risks for blood transfusion and postoperative venous thromboembolism (VTE).
- Recent evidence suggests that tranexamic acid (TA) might be safe in high-risk orthopedic patients, but further research is necessary to confirm this.
- A study analyzing 13,262 elective TKA or THA procedures revealed that TA administration did not significantly affect the odds of VTE or 30-day mortality.
Article Abstract
TKA and THA are associated with blood transfusion and risk for postoperative venothromboembolism (VTE). Reports show that tranexamic acid (TA) may be safe to use in high-risk orthopedic patients, but further data are needed to substantiate its use. All patients who underwent primary or revision TKA or THA in a five year period were retrospectively identified. In 13,262 elective TKA or THA procedures, neither the odds of VTE (OR=0.98; 95% CI 0.67-1.45; P=0.939) or adjusted odds of death (OR=0.26; 95% CI 0.04-1.80; P=0.171) were significant with TA administration. The major findings of this large, single center, retrospective cohort study show the odds of postoperative VTE and 30-day mortality were unchanged with TA administration.
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| http://dx.doi.org/10.1016/j.arth.2014.08.022 | DOI Listing |
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