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Coccydynia Improved by Percutaneous Discectomy.
Cureus
November 2024
Anesthesiology, Showa University School of Medicine, Tokyo, JPN.
Usually, coccydynia cases are caused by herniated discs, with lower back pain and sciatica as initial symptoms. However, whether lumbar disc herniation causes coccydynia without back pain remains unclear. We report a case of lumbar disc herniation diagnosed as the underlying cause of coccydynia by discoblock.
View Article and Find Full Text PDFCausal relationship between hypothyroidism and peripheral neuropathy: a Mendelian randomization study of European ancestry.
Front Endocrinol (Lausanne)
December 2024
Acupuncture Anaesthesia Clinical Research Institute, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Background: Metabolic disorders are significant risk factors for peripheral neuropathy (PN) diseases. However, current clinical observational studies cannot fully determine the causal relationships between hypothyroidism (HT) and PN diseases.
Methods: We performed univariate Mendelian randomization (MR) analyses using single nucleotide polymorphisms (SNPs) associated with hypothyroidism and two diseases clinically presented as HT (autoimmune thyroid disease and benign neoplasm of the pituitary gland and craniopharyngeal duct) as instrumental variables.
Network Pharmacology and In Vivo Experimental Verification of the Mechanism of the Qing'e Pill for Treating Intervertebral Disc Degeneration.
Curr Comput Aided Drug Des
December 2024
Department of Orthopedics, the Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, 410005, China.
Objective: The Qing'e Pill (QEP) is widely used to alleviate low back pain and sciatica caused by Intervertebral Disc Degeneration (IDD). However, its active components, key targets, and molecular mechanisms are not fully understood. The aim of this study is to elucidate the molecular mechanisms through which the QEP improves IDD using database mining techniques.
View Article and Find Full Text PDFDevelopment and validation of machine learning models for intraoperative blood transfusion prediction in severe lumbar disc herniation.
iScience
November 2024
Department of Spinal Surgery, Guangxi Medical University Affiliated Liuzhou People's Hospital, Liuzhou, China.
Article Synopsis
- Lumbar disc herniation (LDH) is a prevalent source of lower back pain and sciatica, with posterior lumbar interbody fusion (PLIF) being a standard treatment method, prompting a study on predicting blood transfusion needs during surgery.
- This study involved 6,241 patients across 22 medical centers in China and utilized various machine learning techniques to create an optimal predictive model for intraoperative blood transfusion using robust evaluation methods.
- The best-performing model, a simulated annealing support vector machine recursive + stacking model, achieved an area under the curve of 0.884, leading to the creation of a publicly accessible web calculator to aid clinicians in decision-making and improve patient management.
[Lumbar disc herniation].
Orthopadie (Heidelb)
November 2024
Wirbelsäulenzentrum, Schön Klinik München Harlaching, Harlachinger Straße 51, 81547, München, Deutschland.
Background: The most common cause of disc herniation is the degeneration of the intervertebral disc. Consequently, lumbar disc herniations are amongst the most common pathologies of the lumbar spine. Factors that can increase the risk of disc herniation include genetics, weight, occupational risk factors, smoking, as well as a predominantly sedentary profession.
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