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http://dx.doi.org/10.1128/JCM.01912-14 | DOI Listing |
Foods
October 2024
Biotech Agrifood, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de València, 46100 Burjassot, Spain.
Ochratoxin A (OTA) is a mycotoxin produced by and various species, which are known for contaminating agricultural products and posing significant health risks, which include immunotoxicity. This study aims to evaluate the potential of nanostructured lipid carriers (NLCs) loaded with a carotenoid-enriched extract from pumpkin peel ( L.) in mitigating the toxic effects of OTA.
View Article and Find Full Text PDFChembiochem
August 2024
Department of Chemistry, Brown University, Providence, RI 02912, USA.
Hydrogen polysulfides (HS) have emerged as critical physiological mediators that are closely associated with hydrogen sulfide (HS) signaling. HS exhibit greater nucleophilicity than HS while also having electrophilic characteristics, enabling unique activities such as protein S-persulfidation. Despite their physiological importance, mechanisms and reactivities of HS remain inadequately explored due to their inherent instability in aqueous environments.
View Article and Find Full Text PDFBioinform Biol Insights
April 2024
Research Centre for Molecular Biotechnology and Bioinformatics, Universitas Padjadjaran, Bandung, Indonesia.
Enzymatic reactions can be modulated by the incorporation of organic solvents, leading to alterations in enzyme stability, activity, and reaction rates. These solvents create a favorable microenvironment that enables hydrophobic reactions, facilities enzyme-substrate complex formation, and reduces undesirable water-dependent side reactions. However, it is crucial to understand the impact of organic solvents on enzymatic activity, as they can also induce enzyme inactivation.
View Article and Find Full Text PDFMolecules
April 2024
Department of Health Basic Science, Laboratory of Toxicology, State University of Maringa, Avenue Colombo n° 5790, Maringa 87020-900, PR, Brazil.
The uses of natural compounds, such as essential oils (EOs), are limited due to their instability to light, oxygen and temperature, factors that affect their application. Therefore, improving stability becomes necessary. The objective of this study was to prepare inclusion complexes of essential oil (LCEO) with β-cyclodextrin (β-CD) using physical mixing (PM), kneading (KN) and co-precipitation (CP) methods and to evaluate the efficiency of the complexes and their physicochemical properties using ATR-FTIR, FT-Raman, DSC and TG.
View Article and Find Full Text PDFMicrobiol Spectr
March 2024
Department of Medical Technology, Faculty of Medical Sciences, Shubun University, Ichinomiya, Aichi, Japan.
Metallo-β-lactamases (MBLs) represent one of the main causes of carbapenem resistance in the order . To combat MBL-producing carbapenem-resistant , the development of MBL inhibitors can restore carbapenem efficacy for such resistant bacteria. Microbial natural products are a promising source of attractive seed compounds for the development of antimicrobial agents.
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