AI Article Synopsis
- - The study investigated 42 children with post-infectious bronchiolitis obliterans (PIBO), focusing on their clinical features, radiological findings, and treatment outcomes over a five-year period in northern China.
- - Adenovirus was the most prevalent cause of PIBO, with patients frequently experiencing wheezing and breathing difficulties; some needed intensive care and home oxygen therapy.
- - The research concluded that infections from adenovirus and Mycoplasma pneumoniae increase the risk of PIBO, and effective treatment involved using systemic steroids with azithromycin, with diagnostic support from HRCT and pulmonary function tests.
Article Abstract
Background: This study aimed to describe the clinical characteristics, radiological features and outcomes of 42 children with post-infectious bronchiolitis obliterans (PIBO).
Methods: Forty-two children diagnosed with PIBO were prospectively studied at the First Hospital of Jilin University in northern China between January, 2008 and January, 2013. Their clinical characteristics, lung high resolution computed tomography (HRCT) findings and pulmonary function tests were reported.
Results: In children with PIBO, adenovirus was the most common etiologic agent (21/42), followed by Mycoplasma pneumoniae (M. pneumoniae). All of the patients presented with repeated wheezing and tachypnea. In addition, 22 patients required intensive management, while six patients required home oxygen therapy. HRCT findings were consistent with the PIBO diagnosis in all of the patients. Pulmonary function testing was useful in evaluating therapeutic responses. Systemic steroids combined with azithromycin were effective for PIBO treatment.
Conclusions: Severe adenovirus bronchiolitis and M. pneumoniae infections have a higher risk of development for PIBO. HRCT and pulmonary function testing are useful in the diagnosis of PIBO. The degree of airway obstruction did not differ significantly between adenovirus and M. pneumoniae. A combination of steroids and azithromycin offers some benefit in treating these patients.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4181416 | PMC |
| http://dx.doi.org/10.1186/1471-2431-14-238 | DOI Listing |
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