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Nanotechnology strategy for inhibition of PARP1 and IL-17A-associated with neurotoxicity in rats exposed to hospital wastewater.
Naunyn Schmiedebergs Arch Pharmacol
October 2024
Zoology Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
Hospital wastewater (HWW) poses a serious hazard to human health security concerning its high susceptibility to neurodegeneration. Water sources and ecosystems are exposed to a complicated pollution load from a variety of refractory organics and pharmaceutical active composites. This study evaluates the treated newly developed nanocomposite (NiFeO) HWW on the neural injury induced by HWW action in rats.
View Article and Find Full Text PDFPhysiological and metabolic responses in Kök-Börü horses: Correlations with game outcomes.
Vet Med Sci
May 2024
Department of Zootechny, Faculty of Veterinary Medicine, Fırat University, Elazig, Türkiye.
Background: The aim of this study was to examine variations in stress, metabolic, and physiological parameters of horses used in the traditional equestrian team sport of Kök-Börü in relation to winning and losing outcomes.
Material And Methods: To accomplish this, blood samples were taken from horses on four different teams who participated in two separate games, both before and after game. These samples were used to measure levels of cortisol, ACTH, beta-endorphin, adrenaline, noradrenaline, triiodothyronine (T3), and thyroxine (T4) via species-specific commercial ELISA kits.
Mapping Astrocytic and Neuronal μ-opioid Receptor Expression in Various Brain Regions Using MOR-mCherry Reporter Mouse.
Exp Neurobiol
December 2023
Center for Cognition and Sociality, Institute for Basic Science (IBS), Daejeon 34126, Korea.
The μ-opioid receptor (MOR) is a class of opioid receptors characterized by a high affinity for β-endorphin and morphine. MOR is a G protein-coupled receptor (GPCR) that plays a role in reward and analgesic effects. While expression of MOR has been well established in neurons and microglia, astrocytic MOR expression has been less clear.
View Article and Find Full Text PDFChallenges and new opportunities for detecting endogenous opioid peptides in reward.
Addict Neurosci
June 2022
Department of Anesthesiology, Washington University, St Louis, MO, USA.
The endogenous opioid peptide system, comprised of enkephalins, endorphins, dynorphins, and nociceptin, is a highly complex neurobiological system. Opioid peptides are derived from four precursor molecules and undergo several processing events yielding over 20 unique opioid peptides. This diversity together with low concentration and complex processing and release dynamics has challenged research into each peptide's unique function.
View Article and Find Full Text PDFCapsaicin Reduces Ethanol Consumption in C57BL/6 but not DBA/2 Mice.
Clin Psychopharmacol Neurosci
May 2022
Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea.
Objective: Capsaicin, the pungent analgesic substance of hot peppers which produces a burning sensation and pain is known to affect Substance P and central opioid activities. This experiment was designed to test the effect of capsaicin on alcohol consumption in C57BL/6 and DBA/2 mice. These two strains are known to differ in both their alcohol consumption and their endogenous opioid distribution and response to alcohol.
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