Recent trends of polymer mediated liposomal gene delivery system.

Biomed Res Int

Institute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon 200704, Republic of Korea ; Department of Bioinformatics, School of Computer Sciences, Galgotias University, Greater Noida 203201, India.

Published: June 2015

Advancement in the gene delivery system have resulted in clinical successes in gene therapy for patients with several genetic diseases, such as immunodeficiency diseases, X-linked adrenoleukodystrophy (X-ALD) blindness, thalassemia, and many more. Among various delivery systems, liposomal mediated gene delivery route is offering great promises for gene therapy. This review is an attempt to depict a portrait about the polymer based liposomal gene delivery systems and their future applications. Herein, we have discussed in detail the characteristics of liposome, importance of polymer for liposome formulation, gene delivery, and future direction of liposome based gene delivery as a whole.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163454PMC
http://dx.doi.org/10.1155/2014/934605DOI Listing

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