Cryptosporidium species is identified as an important cause of morbidity in children and adults. Prevalence rate as reported from various studies in India is much lower when compared to developed word. Present study was designed to analyze the prevalence of cryptosporidiosis in West Godavari District, Andhra Pradesh. Stool samples from 306 patients suffering with gastrointestinal symptoms were examined for the presence of Cryptosporidium oocysts. A higher prevalence (25%) was found when compared to reports from north east and western India. Cryptosporidium was prevalent in 35-36% of adults, 17% of children and 20% of infants.
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http://dx.doi.org/10.4103/2229-5070.138543 | DOI Listing |
Microbiol Mol Biol Rev
January 2025
Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, India.
Vesicular mechanisms of drug resistance are known to exist across prokaryotes and eukaryotes. Vesicles are sacs that form when a lipid bilayer 'bends' to engulf and isolate contents from the cytoplasm or extracellular environment. They have a wide range of functions, including vehicles of communication within and across cells, trafficking of protein intermediates to their rightful organellar destinations, and carriers of substrates destined for autophagy.
View Article and Find Full Text PDFJ Biomol Struct Dyn
January 2025
Department of Agricultural Convergence Technology, Jeonbuk National University, Jeonju, Republic of Korea.
Cryptosporidiosis is an infection induced by the single-celled protozoan Cryptosporidium parasite. This parasite commonly infects the intestines of humans and animals, leading to gastrointestinal symptoms such as diarrhea, stomach cramps, nausea, and vomiting. Cryptopain protein, a type of cysteine protease found in the genome of plays an important role in cell invasion and its survival.
View Article and Find Full Text PDFBackground: Diarrhoeal diseases claim more than 1 million lives annually and are a leading cause of death in children younger than 5 years. Comprehensive global estimates of the diarrhoeal disease burden for specific age groups of children younger than 5 years are scarce, and the burden in children older than 5 years and in adults is also understudied. We used results from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021 to assess the burden of, and trends in, diarrhoeal diseases overall and attributable to 13 pathogens, as well as the contributions of associated risk factors, in children and adults in 204 countries and territories from 1990 to 2021.
View Article and Find Full Text PDFVet Parasitol Reg Stud Reports
November 2024
Department of Microbiology, Aarupadai Veedu Medical College & Hospital, Puducherry 607403, India. Electronic address:
Context: The contamination of soil by pathogenic protozoan parasites from both human and animal feces, is an important factor in the spread of parasitic infections globally. This contamination also serves as a crucial reservoir for zoonotic diseases, facilitating their transmission. In many developing nations, including India, there's limited documentation on the extent of soil contamination, which poses challenges for implementing effective One Health strategies aimed at controlling these infections.
View Article and Find Full Text PDFPLoS Pathog
September 2024
Division of Biochemistry and Structural Biology, CSIR-Central Drug Research Institute, Lucknow, India.
The Apicomplexa phylum encompasses numerous obligate intracellular parasites, some associated with severe implications for human health, including Plasmodium, Cryptosporidium, and Toxoplasma gondii. The iron-sulfur cluster [Fe-S] biogenesis ISC pathway, localized within the mitochondrion or mitosome of these parasites, is vital for parasite survival and development. Previous work on T.
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