Polymorphisms in TNF and IFNG are associated with clinical characteristics of aplastic anemia in Argentinean population.

Leuk Lymphoma

Laboratorio de Genética Hematológica, Instituto de Medicina Experimental (IMEX)-CONICET/Academia Nacional de Medicina, Ciudad Autónoma de Buenos Aires , Argentina.

Published: June 2015

The impaired hematopoiesis in acquired aplastic anemia (AA) results from immune-mediated mechanisms. We characterized polymorphisms implicated in controlling type-1 cytokine production in 69 patients with AA. Our data suggest that the studied polymorphisms are not associated with susceptibility in the overall AA population. However, the presence of the higher expressing TNF - 308A allele was associated with younger age (p = 0.0297) and more profound neutropenia (p = 0.0312), and over-represented in patients with very severe AA (p = 0.0168). The higher producing IFNG 12 CA-repeat allele showed strong linkage disequilibrium with the + 874T allele, and was associated with a lower hemoglobin level (p = 0.0351). Also, the presence of at least one higher expressing variant was more frequent among patients responding to immunosuppressive treatment (p = 0.0519). Our findings suggest that the presence of higher expressing variants of tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) in AA patient genotypes could be related to clinical parameters, disease severity and therapy outcomes.

Download full-text PDF

Source
http://dx.doi.org/10.3109/10428194.2014.966707DOI Listing

Publication Analysis

Top Keywords

presence higher
12
higher expressing
12
aplastic anemia
8
allele associated
8
polymorphisms tnf
4
tnf ifng
4
associated
4
ifng associated
4
associated clinical
4
clinical characteristics
4

Similar Publications

Infectious viral pathogens significantly impact wild Leporidae populations, particularly , which was listed as 'Endangered' in 2019. Myxomatosis and rabbit haemorrhagic disease are major contributors to severe epizootics with limited long-lasting immunity. This study expanded beyond these well-documented viruses to include a broader spectrum of viruses in 36 wild rabbit carcasses () collected from the field in 2018, 2019, 2021 and 2024, and 32 wild rabbits hunted in 2017/2018.

View Article and Find Full Text PDF

Background: Cervical cancer is the most common gynaecological cancer worldwide, causing morbidity and mortality, especially in developing countries like Nigeria. It develops from premalignant lesions of the cervix. Human immune deficiency virus (HIV) increases the risk of dysplastic changes in the cervix.

View Article and Find Full Text PDF

Introduction: Type 1 diabetes is often accompanied by autoimmune thyroid disease. We aimed to investigate the clinical characteristics of Japanese patients with acute-onset type 1 diabetes and thyroid autoantibodies, focusing on decreased endogenous insulin secretion.

Materials And Methods: We examined 80 patients with acute-onset type 1 diabetes, classifying them into two groups with and without thyroid autoantibodies and compared the clinical characteristics of the two groups.

View Article and Find Full Text PDF

An elevated level of saturated fatty acids (SFAs) can cause non-alcoholic fatty liver disease (NAFLD). While n-3 polyunsaturated fatty acids (PUFAs) were shown to improve NAFLD, the effects of n-6 PUFAs in the liver have not been fully elucidated. We examined the association between NAFLD and n-6 PUFAs, particularly dihomo-γ-linolenic acid (DGLA), in patients with type 2 diabetes.

View Article and Find Full Text PDF

Unraveling the Effects of Reducing and Oxidizing Pretreatments and Humidity on the Surface Chemistry of the Ru/CeO Catalyst during Propane Oxidation.

J Phys Chem C Nanomater Interfaces

January 2025

Department of Surface and Plasma Science, Faculty of Mathematics and Physics, Charles University, V Holešovičkách 2, Prague 180 00, Czechia.

This work investigates the surface chemistry of the Ru/CeO catalyst under varying pretreatment conditions and during the oxidation of propane, focusing on both dry and humid environments. Our results show that the Ru/CeO catalyst calcined in O at 500 °C initiates propane oxidation at 200 °C, achieves high conversion rates above 400 °C, and demonstrates almost no change in activity in the presence of water vapor across the entire studied temperature range of 200-500 °C. Prereduction of the oxidized Ru/CeO catalyst in H significantly enhances its activity, though this enhancement diminishes at higher temperatures.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!