Trophic lesions of the lower limbs are very frequent in diabetic patients, especially after long periods of poor glycemic control. These lesions are caused by some diabetic sequelae, namely neuropathy and angiopathy. The human and social cost of trophic lesions is very high; for this reason education of diabetics who are likely to develop such lesions is extremely important. When trophic lesions have developed, conservative management is based on local and general therapy. Amputation is taken into account only when conservative management has failed.
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Oral complications associated with trigeminal trophic syndrome: A case report.
Spec Care Dentist
December 2024
Department of Oral Medicine, University of Pennsylvania, School of Dental Medicine, Philadelphia, USA.
Introduction: Destruction of the trigeminal (Gasserian) ganglion or peripheral damage to the trigeminal nerve may lead to trigeminal trophic syndrome (TTS), a rare condition characterized by self-inflicted trauma. To date, under 200 cases of TTS are documented in medical literature, with only sparse studies reporting on oral complications secondary to this condition.
Case Report: The following report presents a well-documented case of oral complications associated with TTS in an 83-year-old Caucasian female presenting with right-sided lesions on her nasal ala, scalp, buccal mucosa, and tongue, secondary to self-inflicted injury following their second microvascular decompression for surgical management of trigeminal neuralgia.
Greater Auricular Trophic Syndrome Following Parotidectomy.
WMJ
November 2024
University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Article Synopsis
- - Trigeminal trophic syndrome leads to self-inflicted skin lesions due to nerve damage, while greater auricular trophic syndrome can develop after nerve sacrifice during parotid surgery.
- - A 59-year-old woman experienced ear ulceration five months post-parotidectomy, diagnosed with greater auricular trophic syndrome and treated effectively with topical clobetasol and behavioral changes.
- - Unlike other reported cases that involved mental health issues, this case involved a patient without prior psychiatric disorders, demonstrating successful treatment focusing on physical symptoms rather than psychological factors.
Advances in Mesenchymal Stem Cell Research Applications for Female Infertility-Mechanisms, Efficacy Parameters, Challenges and Future Roadmap.
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View Article and Find Full Text PDFConquering Insulin Network Dysfunctions in Alzheimer's Disease: Where Are We Today?
J Alzheimers Dis
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Departments of Pathology and Laboratory Medicine, Medicine, Neurology and Neurosurgery, Rhode Island Hospital, Lifespan Academic Institutions, and the Warren Alpert Medical School of Brown University, Providence, RI, USA.
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- Impairments in insulin and IGF signaling in the brain contribute to energy metabolism issues, which are linked to the neurodegeneration seen in Alzheimer's disease, resulting in various brain cell damage and cognitive decline.
- Similar neuropathological processes are observed in other conditions like type 2 diabetes and Parkinson's disease, suggesting common underlying mechanisms.
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Periocular Involvement in Trigeminal Trophic Syndrome.
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Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust, London, GBR.
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- Trigeminal trophic syndrome (TTS) is a rare condition caused by damage to the trigeminal nerve, leading to facial ulceration, loss of sensation, and abnormal skin sensations, especially near the nostrils.
- The lesions associated with TTS arise from continuous self-harm and trauma to the affected skin area.
- This report showcases three individual cases of TTS, emphasizing changes around the eyes and different causes such as strokes and herpes zoster infection.
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