AI Article Synopsis
- Polydatin, derived from the herb Polygonum cuspidatum, was studied for its potential protective effects against learning and memory issues caused by hypoxic-ischemic brain injury (HIBI) in neonatal rats.
- The study found that neonatal rats with induced HIBI exhibited memory deficits, but those treated with polydatin showed improved long-term learning and memory abilities.
- It was also discovered that polydatin increases the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus, suggesting that its protective effects against brain tissue injury and memory impairment may involve the enhancement of BDNF levels.
Article Abstract
Polydatin is a key component of Polygonum cuspidatum, a herb with medical and nutritional value. The present study investigated the protective effect of polydatin against learning and memory impairment in neonatal rats with hypoxic‑ischemic brain injury (HIBI). The unilateral common carotid artery ligation method was used to generate neonatal HIBI rats. Y‑maze testing revealed that rats with HIBI exhibited memory impairment, while rats with HIBI treated with polydatin displayed enhanced long‑term learning and memory. Of note, polydatin was found to upregulate the expression of hippocampal brain‑derived neurotrophic factor (BDNF) in rats with HIBI. BDNF has a role in protecting HIBI‑induced brain tissue injury and alleviating memory impairment. These findings showed that polydatin had a protective effect against learning and memory impairment in neonatal rats with HIBI and that the protective effect may be mediated through the upregulation of BDNF.
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| http://dx.doi.org/10.3892/mmr.2014.2577 | DOI Listing |
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