Major injury is the sixth leading cause of death worldwide. Among those under 35 years of age, it is the leading cause of death and disability. Traffic accidents alone are the main cause, fundamentally in low- and middle-income countries. Patients over 65 years of age are an increasingly affected group. For similar levels of injury, these patients have twice the mortality rate of young individuals, due to the existence of important comorbidities and associated treatments, and are more likely to die of medical complications late during hospital admission. No worldwide, standardized definitions exist for documenting, reporting and comparing data on severely injured trauma patients. The most common trauma scores are the Abbreviated Injury Scale (AIS), the Injury Severity Score (ISS) and the Trauma and Injury severity Score (TRISS). Documenting the burden of injury also requires evaluation of the impact of post-trauma impairments, disabilities and handicaps. Trauma epidemiology helps define health service and research priorities, contributes to identify disadvantaged groups, and also facilitates the elaboration of comparable measures for outcome predictions.
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http://dx.doi.org/10.1016/j.medin.2014.06.012 | DOI Listing |
Phys Rev Lett
December 2024
Indian Institute of Technology, Department of Physics, -Bombay, Powai, Mumbai 400076, India.
Exploring continuous time crystals (CTCs) within the symmetric subspace of spin systems has been a subject of intensive research in recent times. Thus far, the stability of the time-crystal phase outside the symmetric subspace in such spin systems has gone largely unexplored. Here, we investigate the effect of including the asymmetric subspaces on the dynamics of CTCs in a driven dissipative spin model.
View Article and Find Full Text PDFJ Vis Exp
January 2025
Mechanical, Aerospace, and Biomedical Engineering, University of Tennessee;
Cardiovascular disease (CVD) is the leading cause of death in the United States. Damage in the cardiovascular system can be due to environmental exposure, trauma, drug toxicity, or numerous other factors. As a result, cardiac tissue and vasculature undergo structural changes and display diminished function.
View Article and Find Full Text PDFBiofactors
January 2025
Natural Products and Analytical Chemistry Laboratory, MIGAL - Galilee Research Institute, Kiryat Shemona, Israel.
Atherosclerosis is a major cause of morbidity and mortality worldwide; in Israel, ischemic heart disease is the second leading cause of death for both genders aged 45 and above. Atherosclerosis involves stiffening of the arteries due to the accumulation of lipids and oxidized lipids on the blood vessel walls, triggering the development of artery plaque. Coronary artery disease (CAD) is the most common manifestation of atherosclerosis.
View Article and Find Full Text PDFInt J Gynecol Cancer
January 2025
Department of Radiation Oncology, Hospital of The University of Pennsylvania, Philadelphia, PA, USA; Botswana-University of Pennsylvania Partnership, Princess Marina Hospital, Gaborone, Botswana. Electronic address:
Objective: Cervical cancer is a leading cause of cancer-related deaths among women, with a disproportionate burden in sub-Saharan Africa. Understanding the cervical cancer stage and outcomes is crucial for developing effective interventions and reducing its burden. We aimed to undertake a systematic review and meta-analysis of cervical cancer stage distribution and survival outcomes in Africa.
View Article and Find Full Text PDFDalton Trans
January 2025
MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, Guangdong Basic Research Center of Excellence for Functional Molecular Engineering, School of Chemistry, Sun Yat-sen University, Guangzhou, 510275, P. R. China.
Photodynamic therapy (PDT), as a non-invasive cancer treatment, offers significant advantages including high temporal-spatial selectivity, minimal surgical intervention, and low toxicity, thereby garnering considerable research interest from across the world. In this study, we have developed a series of dinuclear cyclometalated Ir(III) complexes as potential two-photon photodynamic anticancer agents. These Ir(III) complexes demonstrate significant two-photon absorption (2PA) cross-sections ( = 66-166 GM) and specifically target mitochondria.
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