In this study, we propose a continuous model for a pathfinding system. We consider acyclic graphs whose vertices are connected by unidirectional edges. The proposed model autonomously finds a path connecting two specified vertices, and the path is represented by a stable solution of the proposed model. The system has a self-recovery property, i.e., the system can find a path when one of the connections in the existing path is suddenly terminated. Further, we demonstrate that the appropriate installation of inhibitory interaction improves the search time.
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http://dx.doi.org/10.1016/j.neunet.2014.08.008 | DOI Listing |
PLoS Genet
January 2025
Department of Molecular Biosciences, Program in Molecular, Cellular, and Developmental Biology, KU Center for Genomics, University of Kansas, Lawrence, Kansas, United States of America.
Recent studies in vertebrates and Caenorhabditis elegans have reshaped models of how the axon guidance cue UNC-6/Netrin functions in dorsal-ventral axon guidance, which was traditionally thought to form a ventral-to-dorsal concentration gradient that was actively sensed by growing axons. In the vertebrate spinal cord, floorplate Netrin1 was shown to be largely dispensable for ventral commissural growth. Rather, short range interactions with Netrin1 on the ventricular zone radial glial stem cells was shown to guide ventral commissural axon growth.
View Article and Find Full Text PDFNat Commun
December 2024
The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Deafness is the most common form of sensory impairment in humans and frequently caused by defects in hair cells of the inner ear. Here we demonstrate that in male mice which model recessive non-syndromic deafness (DFNB6), inactivation of Tmie in hair cells disrupts gene expression in the neurons that innervate them. This includes genes regulating axonal pathfinding and synaptogenesis, two processes that are disrupted in the inner ear of the mutant mice.
View Article and Find Full Text PDFJ Chem Inf Model
December 2024
Computer-Aided Drug Design Center, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland Baltimore, Baltimore, Maryland 21201, United States.
Drug efficacy often correlates better with dissociation kinetics than binding affinity alone. To study binding kinetics computationally, it is necessary to identify all of the possible ligand dissociation pathways. The site identification by ligand competitive saturation (SILCS) method involves the precomputation of a set of maps (FragMaps), which describe the free energy landscapes of typical chemical functionalities in and around a target protein or RNA.
View Article and Find Full Text PDFPeerJ Comput Sci
November 2024
Department of Mechatronics Engineering, Bursa Technical University, Bursa, Türkiye.
The integration of artificial intelligence into the field of robotics enables robots to perform their tasks more meaningfully. In particular, deep-learning methods contribute significantly to robots becoming intelligent cybernetic systems. The effective use of deep-learning mobile cyber-physical systems has enabled mobile robots to become more intelligent.
View Article and Find Full Text PDFFront Cell Dev Biol
October 2024
Department Molecular Genetics of the Faculty of Medicine, Biocenter, University of Würzburg, Würzburg, Germany.
Spt4 and Spt5 form the DRB sensitivity inducing factor (DSIF) complex that regulates transcription elongation at multiple steps including promotor-proximal pausing, processivity and termination. Although this implicated a general role in transcription, several studies pointed to smaller sets of target genes and indicated a more specific requirement in certain cellular contexts. To unravel common or distinct functions of Spt4 and Spt5 , we generated knock-out alleles for both genes in .
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