AI Article Synopsis
- - The "ALLOVIR" consortium is studying how CMV and BKV infections impact innate immune responses to viruses and transplanted tissues (alloantigens).
- - The project aims to understand the relationship between adaptive immune responses to both viral infections and transplanted tissues, focusing on the concept of heterologous immunity.
- - Researchers will explore how these immune responses affect organ transplants by analyzing tissue and urine, while also examining the influence of immunosuppressive drugs on these responses.
Article Abstract
In the consortium "ALLOVIR" we aim to characterize the effect of CMV and BKV infections on the innate immune responses to viral and alloantigens. Furthermore, we want to characterize the interplay between adaptive immune responses to viral and alloantigens with emphasis on the role of heterologous immunity. Thirdly, we will characterize the manifestations of these immune responses in the allograft, as reflected in tissue and urine, and their correlation with graft function. Finally, we will assess how immunosuppressive drugs interfere with these cross-reactive immune responses.
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| http://dx.doi.org/10.1016/j.trim.2014.09.004 | DOI Listing |
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