AI Article Synopsis
- An easy method for creating uncommon 2-propargylbenzaldehydes was established, which serve as effective building blocks.
- These compounds are used to synthesize 3-benzyl isoquinolines through a microwave-assisted process involving domino imination and cycloisomerization with ammonium acetate.
- A small collection of 3-benzyl isoquinolines was successfully produced in good yields using mild conditions, and two possible reaction mechanisms were suggested.
Article Abstract
An easy entry to uncommon 2-propargylbenzaldehydes was developed. 2-Propargylbenzaldehydes demonstrated to be suitable building blocks for the synthesis of 3-benzyl isoquinolines by microwave promoted domino imination/cycloisomerisation in the presence of ammonium acetate. A small library of 3-benzyl isoquinolines was obtained in good yields under mild reaction conditions. Two alternative plausible reaction mechanisms are proposed.
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| http://dx.doi.org/10.1039/c4ob01583e | DOI Listing |
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