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Fluralaner treatment of chickens kills the southern house mosquito, Culex quinquefasciatus.
Med Vet Entomol
November 2024
Department of Entomology, Texas A&M University, College Station, Texas, USA.
The control of zoonotic and vector-borne pathogens is challenging due to the limited availability of intervention tools. West Nile virus (WNV) is an example of a globally distributed zoonotic arbovirus that circulates between Culex species (Diptera: Culicidae) mosquitoes and avian hosts, with spillover transmission to humans, resulting in disease cases. Interventions delivering systemic insecticides to vertebrate hosts used by vector species, known as xenointoxication, are potential tools for managing vector populations by creating toxic bloodmeals.
View Article and Find Full Text PDFNanoformulated fenbendazole as an attractive approach for treating neurocysticercosis: and studies.
Pharm Dev Technol
December 2024
Laboratory of Host-Parasite Relationship Studies, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goias, Brazil.
Purpose: This work aimed to develop fenbendazole nanocrystals to evaluate their effects on the energetic metabolism of cysticerci, following an intracranial inoculation in mice.
Methods: Fenbendazole was nanoformulated by the antisolvent method using poloxamers 188 and 407 as stabilizers. The nanosuspensions were lyophilized without cryoprotectants and the nanocrystals were characterized in terms of particle size, zeta potential, and dissolution performance.
Formulation and optimization of chitosan-based amorphous fenbendazole microparticles through a design of experiment approach.
Int J Pharm
December 2024
Instituto de Química Rosario-Consejo Nacional de Investigaciones Científicas y Técnicas (IQUIR-CONICET), Suipacha 531, Rosario 2000, Argentina; Área Técnica Farmacéutica, Departamento de Farmacia, Facultad de Ciencias Bioquímicas y Farmacéuticas, Suipacha 531, Universidad Nacional de Rosario, Rosario 2000, Argentina. Electronic address:
Fenbendazole is a broad-spectrum anthelmintic used in veterinary medicine. It is a lipophilic benzimidazole derivative with low water solubility (<0.1 g/L) recently studied for repositioning in cancer treatment.
View Article and Find Full Text PDFFenbendazole and Diisopropylamine Dichloroacetate Exert Synergistic Anti-cancer Effects by Inducing Apoptosis and Arresting the Cell Cycle in A549 Lung Cancer Cells.
Anticancer Res
November 2024
Nimni-Cordoba Tissue Engineering and Drug Discovery Lab, Department of Surgery, Keck School of Medicine of University of Southern California, Los Angeles, CA, U.S.A.
Background/aim: Lung cancer is the leading cause of cancer-related mortality worldwide, accounting for approximately 2 million new cases and 1.8 million deaths annually. Standard treatment options include surgery, radiation therapy, chemotherapy, and targeted therapies.
View Article and Find Full Text PDFGBP2 Regulates Lipid Metabolism by Inhibiting the HIF-1 Pathway to Alleviate the Progression of Allergic Rhinitis.
Cell Biochem Biophys
October 2024
Department of Otolaryngology-Head and Neck Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Article Synopsis
- Allergic rhinitis (AR) is a common allergic condition caused by various allergens, and the study investigates how Guanylate-binding protein 2 (GBP2) affects AR.
- Researchers created an AR model in mice using ovalbumin (OVA) and found that elevated levels of IgE, IgG1, inflammation markers, and abnormal lipid profiles were present in these mice.
- The study showed that GBP2 could reduce inflammation, oxidative stress, and lipid metabolism changes by inhibiting the HIF-1 pathway, suggesting a potential treatment approach for AR.
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