Background: Retinol-binding protein 4 (RBP4) is an adipokine associated with insulin resistance (IR) and obesity-related metabolic disorders. To evaluate its association with cardiovascular disease, we compared serum RBP4 concentrations in patients with coronary artery disease (CAD) and in controls.
Methods: Sixty patients with coronary angiography-confirmed CAD, including 30 with CAD and 30 with CAD and hyperinsulinemia (CAD/HIns group), and 29 healthy subjects were enrolled. Serum RBP4, IR indexes and cardiovascular risk factors were assessed in these subjects.
Results: Serum RBP4 concentrations were significantly higher in the CAD/HIns than in the CAD and control groups (P < 0.01 each). RBP4 concentration was significantly associated with cardiovascular risk factors, including body mass index and concentrations of triglycerides, high-density lipoprotein cholesterol, uric acid, high-sensitivity C reactive protein and adiponectin (P < 0.01 each). Two-hour postprandial insulin (β = 0.224), homeostatic model assessment of IR score (β = 0.456) and adiponectin concentration (β = 0.294) were independent factors associated with RBP4 (P < 0.01 each).
Conclusions: RBP4 concentration is associated with cardiovascular risk factors related to IR and CAD. Circulating RBP4 could be a marker of metabolic complications and atherosclerosis and could be used to assess CAD.
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http://dx.doi.org/10.1097/MAJ.0000000000000347 | DOI Listing |
Antimicrob Resist Infect Control
January 2025
Department of Pediatrics, College of Medicine, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul, Republic of Korea.
Background: Clinical characteristics and outcomes of carbapenem-resistant Enterobacterales (CRE) infection and colonization have rarely been reported in patients with severe burns, who are prone to severe bacterial infections. This study aimed to evaluate clinical characteristics and outcomes of CRE infection and colonization in patients with severe burns.
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Neurol Res Pract
January 2025
Institute of Clinical Epidemiology and Biometry, Julius-Maximilians-Universität Würzburg (JMU), Haus D7, Josef-Schneider-Straße 2, 97080, Würzburg, Germany.
Background: Comprehensive clinical data regarding factors influencing the individual disease course of patients with movement disorders treated with deep brain stimulation might help to better understand disease progression and to develop individualized treatment approaches.
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J Cardiothorac Surg
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Semmelweis University Heart and Vascular Centre, Budapest, 1122, Hungary.
Background: Aortic dissection occurs rarely during pregnancy but carries a significantly high vital risk for both the mother and the fetus. Early diagnosis and treatment are critical for a successful outcome.
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Eur J Med Res
January 2025
The Department of Pediatrics, The Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan, China.
Background: The systemic immune-inflammation index (SII) is an emerging marker of inflammation, and the onset of psoriasis is associated with inflammation. The aim of our study was to investigate the potential impact of SII on the incidence rate of adult psoriasis.
Methods: We conducted a cross-sectional study based on the National Health and Nutrition Examination Survey (NHANES) 2011-2014 data sets.
J Cardiothorac Surg
January 2025
Department of Cardiology, The first Affiliated Hospital of Wannan, Medical College, Wuhu, China.
Background: He's team have recently developed a new Coronary Artery Tree description and Lesion EvaluaTion (CatLet) angiographic scoring system, which is capable of accounting for the variability in coronary anatomy, and risk-stratifying patients with coronary artery disease. Preliminary studies have demonstrated its superiority over the the Synergy between percutaneous coronary intervention with Taxus and Cardiac Surgery (SYNTAX) score with respect to outcome predictions for acute myocardial infarction (AMI) patients. However, there are fewer studies on the prognostic in chronic coronary artery disease(CAD).
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