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Enhanced synergism of thermo-chemotherapy by combining highly efficient magnetic hyperthermia with magnetothermally-facilitated drug release. | LitMetric

Enhanced synergism of thermo-chemotherapy by combining highly efficient magnetic hyperthermia with magnetothermally-facilitated drug release.

Nanoscale

Institute of Nano and Bio-Polymeric Materials, School of Materials Science and Engineering, Tongji University, Shanghai 201804, China.

Published: November 2014

AI Article Synopsis

  • A new nanocarrier was created that responds to heat and magnetic fields for improved cancer treatment by combining magnetic hyperthermia (MH) with drug release capabilities.
  • The system enhances the destruction of tumor cells through a process that helps the cells absorb the treatment better.
  • It also triggers the overproduction of Heat Shock Proteins, which further aids in killing cancer cells.

Article Abstract

A magnetothermally-responsive nanocarrier was developed for efficient thermo-chemotherapy by combining efficient magnetic hyperthermia (MH) and magnetothermally-facilitated drug release. The effective magnetothermal-response contributed to high enhancement of tumor cell killing by an operating mechanism involving MH-facilitated cellular uptake and Heat Shock Protein over-expression.

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Source
http://dx.doi.org/10.1039/c4nr03384aDOI Listing

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