Objective: Brain white matter hyperintensities can be divided into periventricular hyperintensity (PVH) and deep-and-subcortical white matter hyperintensity (DSWMH); the former contributes more to cognitive dysfunction and infarction risk. We conducted the present investigation to define the relationship between PVH and DSWMH.
Design: Cross-sectional study.
Setting: University hospital.
Participants: We prospectively enrolled 228 healthy Japanese volunteers with relative risk values (RRVs) >0.5.
Primary Outcome Measures: We investigated whether it is possible to use the RRV to predict PVH and DSWMH.
Results: Among 228 volunteers, 103 (45.1%) and 157 (68.8%) exhibited PVH and DSWMH, respectively. Age, body mass index and PVH were significant independent determinants of RRV. A significant OR for PVH was noted in the highest RRV tertile compared with the lowest, after adjusting for potential confounding factors. A significant OR for high predicted PVH risk was found for RRV levels as well.
Conclusions: Elevated RRV levels were significantly associated with increased predicted PVH, suggesting that measuring the plasma protein-conjugated acrolein, interleukin 6 and C reactive protein levels may be useful for identifying Japanese at high risk for PVH.
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| http://dx.doi.org/10.1136/bmjopen-2014-005598 | DOI Listing |
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