We intend to identify the relationship between Klotho protein and elderly hypertension. Serous Klotho protein and nitric oxide (NO) which gathered from 79 elderly hypertensive patients, 30 elderly non-hypertensive patients and 25 non-elderly hypertensive patients were detected by ELISA and nitro-reductase method, respectively; and the comparison came from the former group and the last two groups. The results were as follows: Klotho protein absorbance (0.303 ± 0.096) and NO concentrations (43.95 ± 21.85 μmol/L) in elderly hypertensive group were lower than the elderly non-hypertensive group (0.489 ± 0.216) and (62.63 ± 21.26 μmol/L). So it shows that there was significant difference between the two groups (P < 0.01). And the result suggested that, except of the contribution of Klotho protein to the calcification of vessel wall and reduction of vascular elasticity, elderly hypertension may partially attributes to the reduction of serous Klotho protein, which leads to the shrinkage of endothelial function companied with decrease of NO.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161594 | PMC |
Publication Analysis
Top Keywords
Similar Publications
Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
The Jackson Laboratory, Bar Harbor, ME, USA.
Background: Apolipoprotein E4 (APOE4), a common variant of APOE, is a major genetic risk factor for Alzheimer's disease (AD), but APOE4 carriers do not always develop AD. Several large-scale genetic studies have identified a common haplotype of the aging factor klotho that modify disease risk in APOE4 carriers. In humans, klothoharbors two common missense variants (rs9536314, p.
View Article and Find Full Text PDFConformational landscape of soluble α-klotho revealed by cryogenic electron microscopy.
Sci Rep
January 2025
Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA.
α-Klotho (KLA) is a type-1 membranous protein that can associate with fibroblast growth factor receptor (FGFR) to form co-receptor for FGF23. The ectodomain of unassociated KLA is shed as soluble KLA (sKLA) to exert FGFR/FGF23-independent pleiotropic functions. The previously determined X-ray crystal structure of the extracellular region of sKLA in complex with FGF23 and FGFR1c suggests that sKLA functions solely as an on-demand coreceptor for FGF23.
View Article and Find Full Text PDFKlotho enhances stability of chronic kidney disease atherosclerotic plaques by inhibiting GRK2/PLC-β-mediated endoplasmic reticulum stress in macrophages via modulation of the ROS/SHP1 pathway.
Sci Rep
December 2024
Division of Nephrology, Affiliated Hospital of Hebei University, Baoding, China.
Klotho has been importantly linked to atherosclerosis, but little is known about its specific role. This study investigates the mechanism by which Klotho enhances the stability of atherosclerotic plaques in chronic kidney disease. apoE-/- knockout mice and C57BL/6 mice underwent 5/6 nephrectomy and then klotho-NC and klotho-mimic groups were set up to be fed a high-fat chow diet and a dummy group was created to be fed a normal chow diet.
View Article and Find Full Text PDFCorrelation of the weight-adjusted waist circumference index with Klotho in the United States: differences by sex.
Sci Rep
December 2024
Geriatric Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
The relationship between the weight-adjusted waist circumference index (WWI) and the senescence-inhibitory protein Klotho remains unknown. Therefore, this study aimed to investigate the relationship between WWI and soluble Klotho (s-Klotho). This study analyzed 9,928 participants based on the 2007-2016 National Health and Nutrition Examination Survey (NHANES).
View Article and Find Full Text PDFAssociation Between Visceral Fat and Lung Function Impairment in Overweight and Grade I Obese Women: A Cross-Sectional Study.
Adv Respir Med
December 2024
Laboratory of Pulmonary and Exercise Immunology (LABPEI), Evangelical University of Goiás (UniEvangélica), Avenida Universitária Km 3,5, Anápolis 75083-515, GO, Brazil.
Beyond the common comorbidities related to obesity, such as type 2 diabetes and cardiovascular diseases, impaired lung function is already known, but whether the fat distribution (sub-cutaneous, visceral) affects the lung function and pulmonary immune response are poorly known. Few evidence has shown that visceral fat is associated with insulin resistance, low-grade inflammation, and reduced lung function. In the present study, the body composition and fat distribution were evaluated by multi-frequency octopolar bioimpedance.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!