AI Article Synopsis
- Researchers are studying if special immune cells called regulatory T cells (Tregs) in animals with chronic viral infections can affect how the immune system reacts to new, different viruses.
- They found that Tregs in mice with a long-lasting virus reduced the ability of the immune system to fight off a new virus.
- Interestingly, the new virus did not make more Tregs or activate them in the body.
Article Abstract
It is still unclear whether expanded and activated regulatory T cells (Tregs) in chronic viral infections can influence primary immune responses against superinfections with unrelated viruses. Expanded Tregs found in the spleens of chronically Friend virus (FV)-infected mice decreased murine cytomegalovirus (mCMV)-specific CD8(+) T cell responses during acute mCMV superinfection. This suppression of mCMV-specific T cell immunity was found only in organs with FV-induced Treg expansion. Surprisingly, acute mCMV infection itself did not expand or activate Tregs.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248960 | PMC |
| http://dx.doi.org/10.1128/JVI.01941-14 | DOI Listing |
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