AI Article Synopsis
- The study investigates the antioxidant effects of three isolated compounds from the Baccharis genus, specifically B. articulata and B. usterii, using TRAP and TBARS assays.
- Compounds 1, 2, and 3 were identified, with compound 2 showing a significant boost to the antioxidant capacity of B. usterii's n-butanol fraction.
- The findings indicate that these compounds, particularly at higher concentrations, effectively protect against lipid peroxidation and hold potential for future medicinal chemistry applications.
Article Abstract
As a continuation of our research on the Baccharis genus, the evaluation of the antioxidant effect by TRAP and TBARS assays of three isolated compounds from n-butanol fractions of B. articulata and B. usterii is reported. The structures of these compounds were established as 4-O-beta-D-glucopyranosyl-3,5-dimethoxybenzyl-methanol (1), 5-O-[E]-dicaffeoylquinic acid (2), and 7-hydroxy-5,4'-dimethoxyflavone (3). In the TRAP assay it was possible to observe an antioxidant effect of both n-butanol fractions at 1.25 microg/mL. Among the isolated compounds, compound 2 displayed a remarkable contribution to the total antioxidant capacity of the n-butanol fraction of B. usterii. Moreover, the n-butanol fractions of both species, compounds 1 and 2 at 40.0 microg/mL were efficient in protection of lipid peroxidation in the TBARS experiment. They are promising lead compounds for use in medicinal chemistry studies.
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