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A retrospective review and observational study of outcomes and safety of bimatoprost ophthalmic solution 0.03% for treating eyelash hypotrichosis. | LitMetric

A retrospective review and observational study of outcomes and safety of bimatoprost ophthalmic solution 0.03% for treating eyelash hypotrichosis.

Dermatol Surg

*Medical Associates Inc., Newport Beach, California; †Private Practice, Boca Raton, Florida; ‡Department of Dermatology, School of Medicine, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina; §Aesthetic Solutions, Chapel Hill, North Carolina; ‖Allergan, Inc., Irvine, California; ¶SCI Scientific Communications and Information, Parsippany, New Jersey.

Published: October 2014

AI Article Synopsis

  • Bimatoprost ophthalmic solution 0.03% has shown effective results and safety in prior studies, but real-world data was previously lacking.
  • A retrospective chart review of 585 patients who used bimatoprost for at least 12 months found a high patient satisfaction rate of 92.5% and a typical usage frequency of about 3 times a week.
  • Although 27.4% of patients reported experiencing adverse events (AEs), only a few were officially documented, and there were no serious AEs or cases of iris hyperpigmentation noted, suggesting that the treatment is both safe and well-tolerated over the long term.

Article Abstract

Background: The efficacy and safety of bimatoprost ophthalmic solution 0.03% for treating hypotrichosis were shown in a randomized controlled trial and in an open-label study. To date, no data on real-world experience have been published.

Objective: To evaluate long-term patient satisfaction, usage patterns, and safety of bimatoprost 0.03% in clinical practice.

Materials And Methods: In this retrospective chart review with a cross-sectional design, adult patients exposed to bimatoprost 0.03% for at least 12 months were randomly sampled from 16 investigational sites. Charts were reviewed for medication usage characteristics and adverse events (AEs). At a study visit, questionnaires eliciting patient-reported outcomes were administered and spontaneously reported AEs were tabulated.

Results: Analysis included 585 subjects with a mean (SD) treatment duration of 19.3 (4.3) months. Patient satisfaction with bimatoprost 0.03% was 92.5%; on average, approximately 3 applications per week maintained benefits. Overall, 27.4% of patients spontaneously recalled experiencing AEs while on treatment; however, patient charts showed that only 4 AEs were documented. No instances of iris hyperpigmentation occurred. No serious or severe AEs were noted.

Conclusion: Treatment with bimatoprost 0.03% for at least 12 months is safe, and long-term use is associated with a high degree of satisfaction.

Download full-text PDF

Source
http://dx.doi.org/10.1097/01.DSS.0000452658.83001.d9DOI Listing

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