our heads rotate in three axes and move in three dimensions, constantly varying the spectral and binaural cues at the ear drums. In spite of this motion, static sound sources in the world are typically perceived as stable objects. This argues that the auditory system-in a manner not unlike the vestibulo-ocular reflex-works to compensate for self motion and stabilize our sensory representation of the world. We tested a prediction arising from this postulate: that self motion should be processed more accurately than source motion. We used an infrared motion tracking system to measure head angle, and real-time interpolation of head related impulse responses to create "head-stabilized" signals that appeared to remain fixed in space as the head turned. After being presented with pairs of simultaneous signals consisting of a man and a woman speaking a snippet of speech, normal and hearing impaired listeners were asked to report whether the female voice was to the left or the right of the male voice. In this way we measured the moving minimum audible angle (MMAA). This measurement was made while listeners were asked to turn their heads back and forth between ± 15° and the signals were stabilized in space. After this "self-motion" condition we measured MMAA in a second "source-motion" condition when listeners remained still and the virtual locations of the signals were moved using the trajectories from the first condition. For both normal and hearing impaired listeners, we found that the MMAA for signals moving relative to the head was ~1-2° smaller when the movement was the result of self motion than when it was the result of source motion, even though the motion with respect to the head was identical. These results as well as the results of past experiments suggest that spatial processing involves an ongoing and highly accurate comparison of spatial acoustic cues with self-motion cues.
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http://dx.doi.org/10.3389/fnins.2014.00273 | DOI Listing |
AJNR Am J Neuroradiol
January 2025
From the Orthopedic Data Innovation Lab (ODIL), Hospital for Special Surgery (A.M.L.S., M.A.F.), Department of Radiology and Imaging, Hospital for Special Surgery Centre (E.E.X, Z.I, E.T.T, D.B.S, J.L.C)and Department of Population Health Sciences, Weill Cornell Medicine (M.A.F), New York, New York, USA.
Background And Purpose: To train and evaluate an open-source generative adversarial networks (GANs) to create synthetic lumbar spine MRI STIR volumes from T1 and T2 sequences, providing a proof-of-concept that could allow for faster MRI examinations.
Materials And Methods: 1817 MRI examinations with sagittal T1, T2, and STIR sequences were accumulated and randomly divided into training, validation, and test sets. GANs were trained to create synthetic STIR volumes using the T1 and T2 volumes as inputs, optimized using the validation set, then applied to the test set.
Adv Sci (Weinh)
January 2025
Institute of Applied Materials, Helmholtz-Zentrum Berlin für Materialien und Energie, Hahn-Meitner-Platz 1, 14109, Berlin, Germany.
The phenomena occurring in a weld seam during advancement of a laser beam over a metallic component are still under dispute. The occurrence and evolution of porosity and the occasional blowout of melt need to be understood. Here, a recently developed X-ray tomoscopy setup is applied, providing one hundred 3D images per second to capture the temporal evolution of the melt pool in an AlSi9Cu3(Fe) die-casting while a laser beam advances.
View Article and Find Full Text PDFCell-type-specific activation of parvalbumin (PV)-expressing neurons in the external globus pallidus (GPe) through optogenetics has shown promise in facilitating long-lasting movement dysfunction recovery in mice with Parkinson's disease. However, its translational potential is hindered by adverse effects stemming from the invasive implantation of optical fibers into the brain. In this study, we have developed a non-invasive optogenetics approach, utilizing focused ultrasound-triggered mechanoluminescent nanotransducers to enable remote photon delivery deep in the brain for genetically targeted neuromodulation.
View Article and Find Full Text PDFJ Orthop
July 2025
Department of Orthopaedic Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Background: Anatomic total shoulder arthroplasty (aTSA) is often delayed due to concerns about a more rapid loss of postoperative improvements in younger, more active patients. This retrospective study investigated the effects of patient age on activity-specific functional outcomes at a minimum of 10 years following aTSA.
Methods: A retrospective review of a shoulder arthroplasty database was performed.
J Orthop
July 2025
Jiangsu Province Hospital of Traditional Chinese Medicine, Department of Orthopedics, Nanjing, 210000, PR China.
Background: Medial meniscus posterior root tears (MMPRTs) significantly contribute to knee dysfunction, leading to abnormal biomechanics and accelerated cartilage degeneration. Arthroscopic transtibial pullout and all-inside repair are two commonly used techniques for treating MMPRTs, each with unique advantages and limitations.
Objective: To compare the clinical and functional outcomes of the transtibial pullout and all-inside repair techniques in the treatment of MMPRTs, with a focus on postoperative recovery, knee function, and complications.
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