How mutations accumulate in genomes is the central question of molecular evolution theories. However, our understanding of this process is far from complete. Drake's rule is a notoriously universal property of genomes from microbes to mammals-the number of (functional) mutations per-genome per-generation is approximately constant within a phylum, despite the orders of magnitude differences in genome sizes and diverse populations' properties. So far, there is no concise explanation for this phenomenon. A formal model for the storage of genetic information suggests that a genome of any species operates near its maximum informational storage capacity, and the mutation rate per-genome per-generation is near its upper limit, providing a simple explanation for the rule with minimal assumptions.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209235 | PMC |
| http://dx.doi.org/10.1007/s00114-014-1235-6 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Rule breakers achieve successful shoulder balance: unraveling the myth of upper instrumented vertebrae selection criteria.
Spine Deform
January 2025
Jackie and Gene Autry Orthopaedic Center, Children's Hospital Los Angeles, Keck School of Medicine of USC, 4650 Sunset Blvd, Mailstop #69, Los Angeles, CA, 90027, USA.
Purpose: This study compared shoulder balance outcomes in "rule breakers" (RB) vs. "rule followers" (RF) based on commonly utilized upper instrumented vertebrae (UIV) selection guidelines.
Methods: Adolescent idiopathic scoliosis (AIS) patients (Lenke 1-4) who underwent posterior spine fusion (PSF) with minimum 2-year follow-up had radiographic measurement of shoulder balance including first rib angle (FRA), T1 tilt, coracoid process height difference (CPHD), and clavicle angle (CA) at preop, postop, 6-month, 1-year, and 2-year timepoints.
Why cost-effectiveness thresholds for global health donors should differ from thresholds for Ministries of Health (and why it matters).
F1000Res
March 2024
Department of Global Health and Development, London School of Hygiene and Tropical Medicine, London, UK.
Healthcare cost-effectiveness analysis is increasingly used to inform priority-setting in low- and middle-income countries and by global health donors. As part of such analyses, cost-effectiveness thresholds are commonly used to determine what is, or is not, cost-effective. Recent years have seen a shift in best practice from a rule-of-thumb 1x or 3x per capita GDP threshold towards using thresholds that, in theory, reflect the opportunity cost of new investments within a given country.
View Article and Find Full Text PDFDevelopment and evaluation of a de-escalation training intervention in adult acute and forensic units: the EDITION systematic review and feasibility trial.
Health Technol Assess
January 2024
Division of Nursing, Midwifery and Social Work, School of Health Sciences, University of Manchester, Manchester, UK.
Background: Containment (e.g. physical restraint and seclusion) is used frequently in mental health inpatient settings.
View Article and Find Full Text PDFDimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Nat Commun
January 2024
Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF.
View Article and Find Full Text PDFBackground: Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS), also known as multisystem inflammatory syndrome in children (MIS-C) emerged in April, 2020. The paediatric comparisons within the RECOVERY trial aimed to assess the effect of intravenous immunoglobulin or corticosteroids compared with usual care on duration of hospital stay for children with PIMS-TS and to compare tocilizumab (anti-IL-6 receptor monoclonal antibody) or anakinra (anti-IL-1 receptor antagonist) with usual care for those with inflammation refractory to initial treatment.
Methods: We did this randomised, controlled, open-label, platform trial in 51 hospitals in the UK.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!