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-β, β-β' trifused porphyrins: synthesis, spectral, electrochemical and DFT studies and their femtosecond third-order nonlinear optical properties.
Dalton Trans
January 2025
Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, 247667, India.
-β, β-β' trifused porphyrins incorporating two distinct active methylene groups (MN = malononitrile and IND = 1,3-indanedione) and their corresponding metal complexes with Cu(II) and Zn(II) have been synthesized with good to excellent yields and characterized by various spectroscopic techniques and spectrometric methods. Single crystal X-ray analysis of the Zn(II) complex ZnTFPMB(MN) (where TFP = trifused porphyrin and MB = mono benzo) revealed a nonplanar 'armchair' type conformation with a twist angle of 24.10°.
View Article and Find Full Text PDFGenetic analysis and heterosis breeding of seed yield and yieldattributing traits in Indian mustard (Brassica juncea (L.) Czern & Coss.).
Sci Rep
January 2025
Department of Genetics and Plant Breeding, Uttar Banga Krishi Viswavidyalaya, Pundibari, CoochBehar, West Bengal, India.
This study aimed to assess the genetic basis and combining ability of 10 morphological traits in Indian mustard. The experiment involved eight parent lines and 28 crosses derived from a half-diallel mating design. Combining ability analysis is vital for identifying parents and hybrids with favorable genetic effects to enhance breeding efficiency.
View Article and Find Full Text PDFNovel 327bp Alu element insertion in LDLR exon 17 causes alternative splicing and familial hypercholesterolemia.
J Clin Lipidol
December 2024
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India; Apollo Genomics Institute, Indraprastha Apollo Hospital, New Delhi, 110076, India. Electronic address:
Background: Homozygous familial hypercholesterolemia (HoFH) is a severe form of familial hypercholesterolemia (FH), characterized by high low-density lipoprotein cholesterol (LDL-C) levels and increased coronary artery disease risk. This study reports a novel Alu insertion in the LDLR gene in a consanguineous Indian family, causing FH.
Objective: To identify and characterize the mutation causing HoFH in a proband and their family members.
Itaconate mechanism of action and dissimilation in .
Proc Natl Acad Sci U S A
January 2025
Centre for Tuberculosis Research, Tuberculosis Research Laboratory, Translational Health Science and Technology Institute, National Capital Region Biotech Science Cluster 3rd Milestone, Faridabad, Haryana 121001, India.
Itaconate, an abundant metabolite produced by macrophages upon interferon-γ stimulation, possesses both antibacterial and immunomodulatory properties. Despite its crucial role in immunity and antimicrobial control, its mechanism of action and dissimilation are poorly understood. Here, we demonstrate that infection of mice with increases itaconate levels in lung tissues.
View Article and Find Full Text PDFPotential Effect of Extracellular Vesicles in Clinical Settings of Lymphoma.
Indian J Clin Biochem
January 2025
Department of Biochemistry, All India Institute of Medical Sciences Rishikesh, Rishikesh, 249203 India.
Liquid biopsy is gaining importance in oncology in the age of precision medicine. Extracellular vesicles (EVs), among other tumor-derived indicators, are isolated and analysed from bodily fluids. EVs are secreted by both healthy and cancerous cells and are lipid bilayer-enclosed particles that are diverse in size and molecular makeup.
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