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Asymmetric dynamics of GABAergic system and paradoxical responses of GABAergic neurons in piriform seizures.
Epilepsia
December 2024
Shanghai Pudong Hospital, Fudan University Pudong Medical Center, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science and Institutes of Brain Science, Fudan University, Shanghai, China.
Objective: The piriform cortex (PC) plays a critical role in ictogenesis, where an excitation/inhibition imbalance contributes to epilepsy etiology. However, the epileptic dynamics of the gamma-aminobutyric acid (GABA) system and the precise role of GABAergic neurons within the PC in epilepsy remain unclear.
Methods: We combined Ca and GABA sensors to investigate the dynamics of Gad2-expressing neurons and GABA levels, and selectively manipulated GABAergic neurons in the PC through chemogenetic inhibition and caspase3-mediated apoptosis targeting Gad2 interneurons.
Taking flight!
Dev Biol
January 2025
Department of Biology, Indiana University, Bloomington, IN, 47405, USA. Electronic address:
Article Synopsis
- The study of novel complex traits, like eyes and limbs, is crucial to evolutionary biology, yet their developmental origins remain unclear.
- Research by Clark-Hachtel, Linz, and Tomoyasu in 2013 focused on insect wings as a case study, revealing how new traits can emerge from the gradual modification of ancestral structures.
- This research redefined our understanding of evolution, emphasizing that innovation arises through ancestral homology and has inspired further exploration in the field.
Evidence supported by Mendelian randomization: impact on inflammatory factors in knee osteoarthritis.
Front Med (Lausanne)
May 2024
Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China.
Background: Prior investigations have indicated associations between Knee Osteoarthritis (KOA) and certain inflammatory cytokines, such as the interleukin series and tumor necrosis factor-alpha (TNFα). To further elaborate on these findings, our investigation utilizes Mendelian randomization to explore the causal relationships between KOA and 91 inflammatory cytokines.
Methods: This two-sample Mendelian randomization utilized genetic variations associated with KOA from a large, publicly accessible Genome-Wide Association Study (GWAS), comprising 2,227 cases and 454,121 controls of European descent.
Epigenetic modifications in solid tumor metastasis in people of African ancestry.
Front Oncol
February 2024
Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, United States.
This review focuses on the critical role of epigenetic modifications in solid tumor metastasis, particularly in people of African ancestry. Epigenetic alterations, such as DNA methylation, histone modifications, alterations in non-coding RNAs, and mRNA methylation, significantly influence gene expression, contributing to cancer development and progression. Despite the primary focus on populations of European, American, and Asian descent in most cancer research, this work emphasizes the importance of studying the unique genetic and epigenetic landscapes of African populations for a more inclusive approach in understanding and treating cancer.
View Article and Find Full Text PDFIterative Residual Optimization Network for Limited-Angle Tomographic Reconstruction.
IEEE Trans Image Process
January 2024
Limited-angle tomographic reconstruction is one of the typical ill-posed inverse problems, leading to edge divergence with degraded image quality. Recently, deep learning has been introduced into image reconstruction and achieved great results. However, existing deep reconstruction methods have not fully explored data consistency, resulting in poor performance.
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