AI Article Synopsis
- A meta-analysis was conducted to determine the impact of biallelic CEBPA (bi CEBPA) mutations on the prognosis of acute myeloid leukemia (AML), analyzing studies up to August 2014.
- Results from ten studies with 6,219 patients indicated that bi CEBPA mutations correlate with significantly improved overall survival (OS) and event-free survival (EFS) in AML patients, especially those with cytogenetically normal AML (CN-AML).
- The findings suggest that bi CEBPA mutations could be a valuable new prognostic marker for better clinical outcomes in AML patients, contrasting with monoallelic or wild-type CEBPA mutations which showed no significant survival differences.
Article Abstract
Objectives: Increasing number of studies suggested that biallelic CEBPA (bi CEBPA) mutations were associated with favorable prognosis in patients with acute myeloid leukemia (AML), but the results remain inconclusive. We therefore present a meta-analysis to evaluate the prognostic value of bi CEBPA mutations in patients with AML.
Methods: A comprehensive literature search was undertaken through August 2014 looking for eligible studies. Pooled hazard ratios (HRs) estimates and 95% confidence intervals (95% CIs) in overall survival (OS) and event-free survival (EFS) were used to calculate estimated effect.
Results: Ten studies covering a total of 6219 subjects were included in this analysis. Overall, bi CEBPA mutations were associated with favorable clinical outcome in patients with AML (HR for EFS: 0.41, 95% CI: 0.32-0.52; for OS: 0.37, 95% CI: 0.27-0.50), in cytogenetically normal (CN)-AML (HR for EFS: 0.38, 95% CI: 0.29-0.49; for OS: 0.32, 95% CI: 0.23-0.43). When took the cohort of monoallelic CEBPA (mo CEBPA) mutated and wild-type CEBPA (wt CEBPA) AML as a reference group, bi CEBPA mutated AML also shown beneficial outcomes (HR for OS: 0.52, 95% CI: 0.37-0.72). No significant difference was found between mo CEBPA mutation and wt CEBPA in patients with AML or CN-AML (P > 0.05).
Conclusion: Bi CEBPA mutations in patients with AML are strongly associated with a favorable prognosis, which suggested that bi CEBPA mutations would potentially serve as a novel prognostic marker in AML.
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| http://dx.doi.org/10.1111/ejh.12450 | DOI Listing |
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