Mycobacterium tuberculosis infection is an important cause of sight-threatening chorioretinitis in HIV-infected individuals living in M. tuberculosis endemic areas. We present a case of tuberculous chorioretinitis in a HIV-infected man after recent initiation of antiretroviral therapy in rural South Africa, who had nearly complete resolution of clinical signs and symptoms after standard tuberculosis treatment. His presentation was most likely associated with immune reconstitution inflammatory syndrome.
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http://dx.doi.org/10.1007/s10792-014-9997-6 | DOI Listing |
J Curr Ophthalmol
October 2024
Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC, Canada.
Purpose: To describe the first reported instance of an acute chorioretinal inflammatory response to cabozantinib.
Methods: Case report.
Results: A 54-year-old Asian male presented with blurred vision 2 weeks following the commencement of cabozantinib for metastatic renal cell carcinoma.
A 61-year-old woman had worsening vision for 12 years associated with progressive patchy macular chorioretinal atrophy. There was latent tuberculosis and angioid streaks. Testing revealed a pathogenic variant of PRPH2 and a heterozygous ABCC6 variant.
View Article and Find Full Text PDFOcul Immunol Inflamm
August 2024
Department of Uvea, Sankara Nethralaya, Chennai, India.
Purpose: To study and compare the clinical characteristics and outcome of ocular syphilis between HIV positive and HIV negative patients.
Methods: Retrospective hospital-based case series from a tertiary eye care hospital in India. Patients with uveitis and positive syphilis serology were included.
Am J Trop Med Hyg
September 2024
Division of Infectious Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Br J Ophthalmol
December 2024
Saroja A Rao Center for Uveitis, LV Prasad Eye Institute, Hyderabad, Telangana, India
Background: Tuberculosis (TB)-immunoreactivity, measured in vivo (tuberculin skin test (TST)) or in vitro (interferon gamma release assay (IGRA)), can be found in latent, active or even following clearance of TB infection. In this case-control study, we compared the systemic and ocular outcomes between patients with or without TB-immunoreactivity, who received immunomodulatory therapy (IMT) for non-infectious uveitis.
Methods: We retrospectively reviewed charts of patients with (cases) or without (controls) TB-immunoreactivity (TST±IGRA), who received conventional IMT for ≥6 months, for the treatment of non-infectious uveitis.
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