AI Article Synopsis
- Late-onset anaphylactic reactions are rare but can occur after intravenous cyclophosphamide (IVCY) administration due to metabolites of the drug.
- A case of a patient with scleroderma and lupus overlap syndrome experienced anaphylactic reactions 3 hours to 4 days post-therapy.
- This delayed response is consistent with type I hypersensitivity to cyclophosphamide metabolites, highlighting the importance of monitoring for this reaction even after a significant time lapse.
Article Abstract
Late-onset anaphylactic reaction is a rare adverse effect of i.v. cyclophosphamide pulse (IVCY), which is caused by cyclophosphamide metabolites. We herein report a case of scleroderma and lupus overlap syndrome who developed anaphylactic reactions 3 h to 4 days after IVCY. Long time lapses between IVCY and appearance of symptoms are compatible with type I hypersensitivity to cyclophosphamide metabolites, appearing as late-onset anaphylactic reaction. Albeit unusual, this is an important anaphylactic reaction to be aware of following IVCY.
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| http://dx.doi.org/10.1111/1346-8138.12619 | DOI Listing |
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