Background And Study Aim: The endoscopic hemostatic therapies currently available do not always result in hemostasis of gastrointestinal bleeding. Oxidized regenerated cellulose (ORC) mesh is a widely available surgical hemostatic material. The aim of this study was to evaluate the hemostatic efficacy of ORC in experimental gastric hemorrhage after endoscopic resection.
Methods: This was a prospective, two-stage experimental, Phase I, proof-of-concept study. In Stage 1, eight gastric mucosal lesions were created in anticoagulated rabbits and treated with ORC (closed or open pores). In Stage 2, the endoscopic introduction and application of ORC mesh pieces were evaluated in a porcine model of endoscopic submucosal dissection (ESD).
Results: In Stage 1, hemostasis was achieved in all lesions. Hemostasis was achieved more rapidly with closed-pore than open-pore ORC (24.5 vs. 66.5 seconds) (P < 0.01). At 24 hours, all lesions showed persistent hemostasis. There were no episodes of rebleeding, complications, or mortality. In Stage 2, the endoscopic introduction of ORC pieces and application with a biopsy forceps were feasible in all ESD lesions.
Conclusions: ORC was an effective hemostatic agent for bleeding lesions following mucosal resection in anticoagulated rabbits. Closed-pore ORC achieved hemostasis faster than open-pore ORC. Endoscopic introduction and release of ORC were feasible.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1055/s-0034-1365494 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Multifunctional hyaluronic acid microneedle patch enhances diabetic wound healing in diabetic infections.
Int J Biol Macromol
January 2025
Department of Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, PR China; Department of Emergency, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, PR China. Electronic address:
Diabetic wounds often exhibit a chronic non-healing state due to the combined effects of multiple factors, including hyperglycemia, impaired angiogenesis, immune dysfunction, bacterial infection, and excessive oxidative stress. Despite the availability of various therapeutic strategies, effectively managing the complex and prolonged healing process of diabetic infected wounds remains challenging. In this study, we combined the natural antidiabetic drug lipoic acid (LA) with the RADA16-YIGSR (RY) peptide obtained through solid-phase synthesis, utilizing reversible hydrogen bonds and coordination bonds for binding.
View Article and Find Full Text PDFDANCR Knockdown Alleviates Neuroinflammation and Functional Recovery after Spinal Cord Injury via Regulating the ACTN4 / STAT3 Axis.
Arch Biochem Biophys
January 2025
Department of Spinal Surgery, Orthopedic Medical Center, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China. Electronic address:
Polarization of microglia following spinal cord injury (SCI) is a pivotal pathological process of secondary injury. Although differentiation antagonistic nonprotein coding RNA (DANCR) has been implicated in immune and inflammatory responses across various diseases, its role in SCI still unclear. This research aimed to clarify the underlying mechanisms of DANCR in SCI recovery by investigating its expression pattern in microglia.
View Article and Find Full Text PDFResveratrol alleviates blast lung injury by modulating the epithelial sodium channel (ENaC) via the PI3K/AKT pathway.
Int Immunopharmacol
January 2025
The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang 450003, Henan, China; Clinical Medical Center of Tissue Engineering and Regeneration, Xinxiang Medical University, Xinxiang 450003, Henan, China. Electronic address:
Blast lung injury (BLI) is a major cause of death in blast injuries, largely due to pulmonary edema. Effective clearance of alveolar fluid is critical for resolving pulmonary edema, with the epithelial sodium channel (ENaC) playing a key role in this process. Resveratrol (RES), a natural compound with known antioxidant and anti-inflammatory properties, has shown promise in treating respiratory diseases.
View Article and Find Full Text PDFGliricidia sepium (Jacq.) Kunth. ex. Walp. leaves-derived biogenic nanohydrogel accelerates diabetic wound healing in rats over 21 days.
Burns
December 2024
Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini, Cairo 11562, Egypt.
This study focused on the potential of Gliricidia sepium (Jacq.) Kunth. ex.
View Article and Find Full Text PDFOptimizing Electronic and Photovoltaic Properties of D-π-A Organic Dyes for DSSCs Using Density Functional Theory.
J Fluoresc
January 2025
Department of Physics \ Collage of Sciences, University of Kufa, Najaf, Iraq.
This research utilizes density functional theory to investigate the ground and excited-state properties of a new series of organic dyes with D-π-A configurations (D1-D6) for their potential application in dye-sensitized solar cells. The study focuses on modifying these dyes using various functional groups as π-bridges to optimize their electronic properties and improve their efficiency as sensitizers in DSSCs. The frontier molecular orbitals (HOMO and LUMO) were analysed to evaluate electron transfer properties.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!