Background: Ex ante impact assessment has become a fundamental tool for effective program management, and thus, a compulsory task when establishing a new program in the European Union (EU).
Objective: This article aims to analyze benefits from ex ante impact assessment, methodologies followed, and difficulties encountered. This is done through the case study on the rural development programs (RDPs) in the EU. Results regarding methodologies are then contrasted with the international context in order to provide solid insights to evaluators and program managing authorities facing ex ante impact assessment.
Research Design: All European RDPs from the period 2007 through 2013 (a total of 88) and their corresponding available ex ante evaluations (a total of 70) were analyzed focusing on the socioeconomic impact assessment.
Results: Only 46.6% of the regions provide quantified impact estimations on socioeconomic impacts in spite of it being a compulsory task demanded by the European Commission (EC). Recommended methods by the EC are mostly used, but there is a lack of mixed method approaches since qualitative methods are used in substitution of quantitative ones. Two main difficulties argued were the complexity of program impacts and the lack of needed program information.
Conclusions: Qualitative approaches on their own have been found as not suitable for ex ante impact assessment, while quantitative approaches-such as microsimulation models-provide a good approximation to actual impacts. However, time and budgetary constraints make that quantitative and mixed methods should be mainly applied on the most relevant impacts for the program success.
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http://dx.doi.org/10.1177/0193841X14552357 | DOI Listing |
Nephrol Dial Transplant
January 2025
Department of Nephrology, Kidney Transplantation and Dialysis, CHU Lille, University of Lille, Lille, France.
Background And Hypothesis: Unlike X-linked or autosomal recessive Alport Syndrome, no clear genotype/phenotype correlation has yet been demonstrated in patients carrying a single variant of COL4A3 or COL4A4.
Methods: We carried out a multicenter retrospective study to assess the risk factors involved in renal survival in patients presenting a single pathogenic variant on COL4A3 or COL4A4.
Results: 97 patients presenting a single pathogenic variant of COL4A3 or COL4A4 were included.
Alzheimers Res Ther
January 2025
Department of Neuroscience "Rita Levi Montalcini", University of Turin, Via Cherasco 15, Turin, 10126, Italy.
Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder with both genetic and environmental factors contributing to its pathogenesis. While early-onset AD has well-established genetic determinants, the genetic basis for late-onset AD remains less clear. This study investigates a large Italian family with late-onset autosomal dominant AD, identifying a novel rare missense variant in GRIN2C gene associated with the disease, and evaluates the functional impact of this variant.
View Article and Find Full Text PDFBMC Psychol
January 2025
Doud Research Group, Khartoum, Sudan.
Introduction: Mental health is crucial for overcoming obstacles, completing tasks, and contributing to society. Mental, social, and cognitive healths are included. In demanding fields like medicine, academic pressure can cause exhaustion, poor performance, and behavioral changes.
View Article and Find Full Text PDFJ Transl Med
January 2025
Department of Biomedical and Biotechnological Sciences, Division of Medical Biochemistry, University of Catania, Catania, Italy.
Background: Clonal myeloproliferation and fibrotic transformation of the bone marrow (BM) are the pathogenetic events most commonly occurring in myelofibrosis (MF). There is great evidence indicating that tumor microenvironment is characterized by high lactate levels, acting not only as an energetic source, but also as a signaling molecule.
Methods: To test the involvement of lactate in MF milieu transformation, we measured its levels in MF patients' sera, eventually finding a massive accumulation of this metabolite, which we showed to promote the expansion of immunosuppressive subsets.
J Exp Clin Cancer Res
January 2025
Hepatology Laboratory, Solid Tumors Program, CIMA, CCUN, University of Navarra, Pamplona, Spain.
Background: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with limited treatment options and a poor prognosis. The critical role of epigenetic alterations such as changes in DNA methylation, histones modifications, and chromatin remodeling, in pancreatic tumors progression is becoming increasingly recognized. Moreover, in PDAC these aberrant epigenetic mechanisms can also limit therapy efficacy.
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