AI Article Synopsis
- MMPs, particularly MMP1, 3, and 7, are thought to play a role in breast cancer invasion and may influence earlier stages of breast cancer development.
- A study analyzed blood samples from 801 breast cancer patients and matched controls to determine the relationship between circulating levels of these MMPs and breast cancer risk.
- The results indicated no significant association between the levels of MMP1, 3, and 7 and overall breast cancer risk, regardless of other factors like body mass index or hormone use.
Article Abstract
Purpose: Matrix metalloproteinases (MMPs), in particular MMP1, 3, and 7, are believed to be critical to breast cancer invasion and metastasis and also may have important functions earlier in breast carcinogenesis. However, the relationship between circulating levels of MMP1, 3, and 7 and breast cancer risk is uncertain.
Methods: We examined associations between plasma MMP1, 3, and 7 and breast cancer risk in a prospective case-control study nested within the Nurses' Health Study. Blood samples were collected from 801 cases who developed breast cancer between 1992 and 2000 and 801 matched controls, and MMP levels were measured via immunofluorescence assay.
Results: No overall association was observed between any of these MMPs and breast cancer risk [top vs. bottom quintile; MMP1: odds ratio (OR) 0.9; 95 % confidence interval (CI) 0.7, 1.3; p-trend = 0.51; MMP3: OR 1.1; 95 % CI 0.8, 1.5; p-trend = 0.88; MMP7: OR = 1.2; 95 % CI 0.8, 1.7; p-trend = 0.18]. Further, findings did not significantly vary by time since blood draw, body mass index, or postmenopausal hormone use, or by breast cancer subtypes.
Conclusions: Circulating MMP1, 3, and 7 levels do not appear to be predictive of overall breast cancer risk.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237657 | PMC |
| http://dx.doi.org/10.1007/s10552-014-0462-7 | DOI Listing |
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