Aims: We assessed the inter-relationship that exists between variations of different biochemical and hematological parameters following strenuous endurance exercise in Ironmen by using multiple factor analysis (MFA). MFA was used to estimate the associations among groups of parameters in order to identify concurrent changes in many different biochemical variables.
Materials & Methods: In total, 14 Ironman athletes were followed before and early after a race. MFA was applied to the parameters that showed a significant variation after the race, as we previously described in detail. Specifically, MFA standardizes data in each group and calculates the global axes (GAs), which are the linear combination of original parameters that maximize the global data variance.
Results: MFA identified three global axes (GAs) as significant, explaining approximately 62% of the global data variance. The first GA contained NT-proBNP, IL-1ra, IL-6, IL-8 and the oxidative index. The second and third GAs included calcium, creatinine, potassium, uric acid, hemoglobin, hematocrit and glucose. Analysis of the first two GAs showed that changes in the oxidative index were associated with variations in IL-8 and NT-proBNP.
Conclusion: Among all the variables considered, MFA evidenced a close relationship between variations in oxidative stress, IL-8 and NT-proBNP, which may have a meaning in the mechanisms related to the physiological response after strenuous acute exercise.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2217/bmm.13.152 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Quantitative lameness assessment in horses by using an accelerometer-based simple device: A preliminary study.
Open Vet J
November 2024
Department of Veterinary Anesthesiology and Surgery, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine Cluj Napoca, Cluj Napoca, Romania.
Background: Global technological advancements have shifted equine lameness diagnostics from purely subjective assessment toward more objective, quantitative methods. Traditional gait evaluations are increasingly being supplemented by innovative technologies to enhance diagnostic accuracy.
Aim: This study aimed to determine if traditional gait assessment could be effectively complemented by quantitative measurements using an affordable, self-constructed device, the Lameness Detector 0.
Morpho-biochemical and molecular profiling for Charcoal Rot (CR) disease resistance in Mung Bean [Vigna radiata (L.) Wilczek] landraces.
Mol Biol Rep
December 2024
ICAR - Indian Institute of Pulses Research, Regional Station, Khordha, 752055, India.
Background: Charcoal Rot (CR) poses a significant threat to mung bean crops by reducing yield, making the development of resistant varieties crucial for stable production and food security. This study evaluated 19 newly identified mung bean landraces using biochemical traits and SSR markers, revealing genetic variability, CR disease reactions, and traits influencing yield and resistance, which provide valuable insights for breeding CR-resistant, high-yielding varieties.
Methods And Results: Mung bean landraces were evaluated for their response to CR using 4 biochemical parameters, and 10 SSR markers to assess genetic variability and disease resistance.
Training of Brazilian indigenous nurses: between human rights, valuing diversity and inclusion.
Rev Bras Enferm
December 2024
Universidade Federal do Pará. Belém, Pará, Brazil.
Objectives: to analyze the possibilities and potential of training indigenous nurses, given the Brazilian Health System (SUS), understanding the relationships between education and health.
Methods: theoretical-reflective study, based on scientific literature, aligned with the experience, critical thinking of its authors and the Sustainable Development Goals in Brazil.
Results: this text articulates three axes: Potential for including indigenous students in nursing training; Paths to achieving equity through inclusion and retention policies for indigenous students at different levels; and Implications of this for the SUS and global health.
CircRNAs and miRNAs: Key Player Duo in Breast Cancer Dynamics and Biomarkers for Breast Cancer Early Detection and Prevention.
Int J Mol Sci
December 2024
Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut 11-0236, Lebanon.
Breast cancer (BC) remains a significant global health issue, necessitating advanced molecular approaches for early detection and prevention. This review delves into the roles of microRNAs (miRNAs) and circular RNAs (circRNAs) in BC, highlighting their potential as non-invasive biomarkers. Utilizing in silico tools and databases, we propose a novel methodology to establish mRNA/circRNA/miRNA axes possibly indicative of early detection and possible prevention.
View Article and Find Full Text PDFShared and specific competing endogenous RNAs network mining in four digestive system tumors.
Comput Struct Biotechnol J
December 2024
Key Laboratory of Computer-Aided Drug Design of Dongguan City, The First Dongguan Affiliated Hospital, School of Pharmacy, Guangdong Medical University, Dongguan 523710, China.
Background: Digestive system malignancies, including esophageal carcinoma (ESCA), stomach adenocarcinoma (STAD), liver hepatocellular carcinoma (LIHC), and colon adenocarcinoma (COAD), pose significant global health challenges. Identifying shared and distinct regulatory mechanisms across these cancers can lead to improved therapies. This study aims to construct and compare competing endogenous RNA (ceRNA) networks across ESCA, STAD, LIHC, and COAD to identify RNA biomarkers that could serve as precision therapeutic targets to enhance clinical outcomes and advance personalized cancer care.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!