AI Article Synopsis
- OxlT is an oxalate transporter from Oxalobacter formigenes, part of the Major Facilitator Superfamily (MFS), which plays a crucial role in moving various solutes across membranes.
- Experimental studies have characterized OxlT as an electrogenic exchanger for oxalate and formate, revealing its three-dimensional structure and its biochemical properties.
- The review compares OxlT’s structure and function with other significant MFS transporters like LacY and GlpT, highlighting its importance in solute transport physiology and potential drug development.
Article Abstract
OxlT, the oxalate transporter of Oxalobacter formigenes, is a member of the Major Facilitator Superfamily of transporters (MFS), one of the largest groups of membrane proteins with substantial relevance to solute transport physiology, pharmacology, and possible drug development. MFS proteins transport a wide range of substrates such as organic and inorganic anions, sugars, drugs, and neurotransmitters. This review succinctly summarizes experimental work on a model MFS protein, OxlT, beginning with its identification as an electrogenic oxalate/formate exchanger, its three-dimensional structure, and discussion of biochemical and biophysical data that have shed further light on its structure and function. We also discuss the structure and function of OxlT in relation to notable MFS carriers such as LacY and GlpT.
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| http://dx.doi.org/10.1007/s00232-014-9728-y | DOI Listing |
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