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Article Abstract
Hepatitis C virus (HCV) infection remains a major health problem worldwide. HCV entry into host cells and membrane fusion are achieved by two envelope glycoproteins, E1 and E2. We report here the 3.5-Å resolution crystal structure of the N-terminal domain of the HCV E1 ectodomain, which reveals a complex network of covalently linked intertwined homodimers that do not harbour the expected truncated class II fusion protein fold.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175578 | PMC |
| http://dx.doi.org/10.1038/ncomms5874 | DOI Listing |
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