AI Article Synopsis
- The study investigates the role of periostin (PN), a secreted glycoprotein, in patients with osteosarcoma and its connection to tumor characteristics and patient prognosis.
- Findings show that higher levels of PN are linked to more aggressive tumor features, such as subtype, size, and stage, indicating it has significant prognostic value.
- The research suggests that PN could be a useful biomarker for identifying osteosarcoma patients with a higher risk of poor outcomes.
Article Abstract
Background: Recent studies have found that periostin (PN), as a kind of secreted glycoprotein, is closely related to the metastatic potential and prognosis of many kinds of tumors. This study aimed to examine the expression of PN in patients with osteosarcoma and explore the relationship of PN expression with clinicopathologic factors and prognosis.
Methods: PN was detected by histopathological and immunohistochemical methods in 62 cases of osteosarcoma and 62 of osteochondroma. Detailed pathological and clinical data were collected by reviewing medical records.
Results: The results showed that increased PN protein expression was prevalent in osteosarcoma and was significantly associated with pathologic subtype (P =0.000), tumor size (P =0.016) and Enneking stage (P =0.047). Additionally, expression of PN was found to be an independent prognostic factor in osteosarcoma patients. High expression of PN protein is closely correlated to the tumor progression and poor survival of osteosarcoma.
Conclusions: Our data suggest that PN is a promising biomarker for identifying individuals with poor prognostic potential and suggests its possible use as a prognostic marker in patients with osteosarcoma.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247611 | PMC |
| http://dx.doi.org/10.1186/1477-7819-12-287 | DOI Listing |
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